174699-00-4

Upstream product

• 57294-38-9 N-(tert-butoxycarbonyl)-4-aminobutanoic acid 
• 174698-99-8 [(S)-1-[(1S,2S)-2-Hydroxy-1-((R)-1-phenyl-ethylcarbamoyl)-propylcarbamoyl]-2-(4-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 174698-98-7 [(1S,2S)-2-Hydroxy-1-((R)-1-phenyl-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester 
• 174699-13-9 (2S,3S)-2-Amino-3-hydroxy-N-((R)-1-phenyl-ethyl)-butyramide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Relevant academic research and scientific papers

Retro-binding thrombin active site inhibitors: Identification of an orally active inhibitor of thrombin catalytic activity

A series of retro-binding inhibitors of human α-thrombin was prepared to elucidate structure-activity relationships (SAR) and optimize in vivo performance. Compounds 9 and 11, orally active inhibitors of thrombin catalytic activity, were identified to be efficacious in a thrombin-induced lethality model in mice.