174702-59-1

Usage

Uses

Used in Chemical Synthesis:
4-Bromo-2-methyl-1-indanone is utilized as a key intermediate in the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable component in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Laboratory Research:
In the field of organic chemistry, 4-Bromo-2-methyl-1-indanone serves as a versatile reagent for conducting specific reactions and experiments. It aids researchers in understanding the behavior of organobromides and ketones, as well as exploring novel synthetic pathways and methodologies.
Used in Pharmaceutical Industry:
4-Bromo-2-methyl-1-indanone is employed as a building block in the development of new pharmaceutical agents. Its structural features can be exploited to create molecules with potential therapeutic applications, contributing to the discovery of innovative drugs for various diseases and conditions.
Used in Agrochemical Development:
In the agrochemical sector, 4-Bromo-2-methyl-1-indanone is used as a precursor in the synthesis of bioactive compounds for crop protection and pest management. Its incorporation into these molecules can enhance their efficacy and selectivity, leading to more effective and environmentally friendly products.

Upstream product

• 1311148-31-8 (E)-3-(2-bromophenyl)-2-methylacrylaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 
• 869063-66-1 3-(2-bromophenyl)-2-methylpropionyl chloride 
• 19829-31-3 1-(3-bromophenyl)-1-propanone 

Downstream Products

• 880652-93-7 4⁽⁷⁾-bromo-2-methyl-1⁽³⁾H-indene 

Relevant academic research and scientific papers

Process for the Preparation of Idnanones

A process of forming compounds of formula I comprising the steps of addition of an amino compound H2NR to a compound of formula (II) followed by cyclization, isomerization and hydrolysis.

Heteroatom bridged metallocene compounds for olefin polymerization

This invention relates to a transition metal compound represented by the formula: wherein M is a group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom; E is: 1) a substituted or unsubstituted indenyl ligand that is bonded to Y through the four, five, six or seven position of the indenyl ring, or 2) a substituted or unsubstituted heteroindenyl ligand that is bonded to Y through the four, five or six position of the heteroindenyl ring, provided that the bonding position is not the same as the position of the ring heteroatom, or 3) a substituted or unsubstituted fluorenyl ligand that is bonded to Y through the one, two, three, four, five, six, seven or eight position of the fluorenyl ring, or 4) a substituted or unsubstituted heterofluorenyl ligand that is bonded to Y through the one, two, three, four, five or six position of the heteroindenyl ring, provided that the bonding position is not the same as the position of the ring heteroatom; A is a substituted or unsubstituted cyclopentadienyl ligand, a substituted or unsubstituted heterocyclopentadienyl ligand, a substituted or unsubstituted indenyl ligand, a substituted or unsubstituted heteroindenyl ligand, a substituted or unsubstituted fluorenyl ligand, a substituted or unsubstituted heterofluorenyl ligand, or other mono-anionic ligand; Y is a Group 15 or 16 bridging heteroatom substituent that is bonded via the heteroatom to E and A; and X are, independently, univalent anionic ligands, or both X are joined and bound to the metal atom to form a metallocycle ring, or both X join to form a chelating ligand, a diene ligand, or an alkylidene ligand. This invention further relates to catalyst systems comprising the above transiotioon metal compounds, activators and optional supports and their use to polymerize or oligomerize olefins.

HALOGEN SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION

A metallocene compound is represented by the formula (1): AMXn-1 wherein M is a transition metal atom having a coordination number of n selected from Group 3, 4, 5 or 6 of the Periodic Table of Elements, or a lanthanide metal atom, or actinide metal atom; A is a substituted monocyclic or polycyclic arenyl ligand pi-bonded to M, wherein said arenyl ligand includes at least one halogen substituent directly bonded to any sp2 carbon atom at a bondable ring position of the ligand; and the or each X is a univalent anionic ligand, or two X are joined and bound to the metal atom to form a metallocycle ring, or two X are joined to form a chelating ligand, a diene ligand, or an alkylidene ligand.

HALOGEN SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION

A metallocene compound is represented by the formula (1): wherein: M is a Group 3, 4, 5 or 6 transition metal atom, or a lanthanide metal atom, or actinide metal atom, preferably a Group 4 transition metal atom selected from titanium, zirconium or hafnium; E is a substituted or unsubstituted monocyclic or polycyclic arenyl ligand pi-bonded to M; A is a substituted or unsubstituted polycyclic arenyl ligand that is pi-bonded to M and has a different ring structure than the E ligand; at least one of the A and E ligands includes at least one halogen substituent directly bonded to an sp2 carbon at a bondable ring position; Y is a bridging group containing at least one Group 13, 14, 15, or 16 element and any single position of the ring structure of A and to any single position of the ring structure of E; and y is zero or 1, indicating the absence (y = 0) or presence (y =1) of Y; and each X is a univalent anionic ligand, or two X are joined and bound to the metal atom to form a metallocycle ring, or two X are joined to form a chelating ligand, a diene ligand, or an alkylidene ligand; provided that when E is an unsubstituted cyclopentadienyl ligand, either y is one or A is not 2-bromofluorenyl or 2,7-dibromofluorenyl.

Preparation of preparing substituted indanones

a process for the preparation of indanones of the formula II from, indanones of the formula I or of indanones of the formula IIa from indanones of the formula Ia comprises reacting an indanone of the formula I or Ia with a coupling component.

Preparation of acrylophenones and 2-alkyl indanones utilizing hexamethylenetetramine as an inexpensive Mannich reagent

Hexamethylenetetramine/acetic anhydride-promoted α-methylenation of aryl alkyl ketones followed by acid-catalyzed cyclization of the resulting acrylophenones produce 2-alkyl indanones in excellent yields.