174727-65-2

Upstream product

• 3764-94-1 5-chlorotryptamine 
• 824-45-3 2,5-dimethylbenzyl chloride 
• 91089-98-4 piperidine-2,3-dione-3-(4-chloro-phenylhydrazone) 
• 103795-47-7 3-(2-aminoethyl)-5-chloro-1H-indole-2-carboxylic acid 
• 17952-83-9 6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one 
• 942-26-7 5-chlorotryptamine hydrochloride 

Downstream Products

• 1053744-89-0 (3aS,4S,6R,6aR)-6-(6-{2-[5-Chloro-1-(2,5-dimethyl-benzyl)-1H-indol-3-yl]-ethylamino}-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole-4-carboxylic acid cyclopropylamide 

Relevant academic research and scientific papers

N6-Substituted Adenosine Receptor Agonists. Synthesis and Pharmacological Activity as Potent Antinociceptive Agents

Novel N6-(indol-3-yl)alkyl derivatives of adenosine were synthesized.The adenosine receptor affinity and the antinociceptive activity of these compounds were assessed in binding studies and the phenylbenzoquinone-induced writhing test.Most of these analogues exhibited a potent analgesic activity without side effects.Among them, compound 3c (UP 202-32) bound to A1 (Ki = 110 nM) and A2 (Ki = 350 nM) adenosine receptors in a specific manner since it did not interact with many other receptors, especially opioid binding sites.The antinociceptive activity in the phenylbenzoquinone assay (ED50 = 3.3 mg/kg po) was antagonized by 8-cyclopentyltheophylline, suggesting that an adenosinergic mechanism underlies the analgesic activity observed with this compound.The data obtained with these new N6-substituted adenosine receptor agonists emphasize the interest of such compounds in the treatment of pain.

New Synthesis of 1-Substituted 3-(2-Aminoethyl)indoles

A number of 1-substituted 3-(2-aminoethyl)indoles were prepared, in one step, by alkylation of the corresponding 3-(2-aminoethyl)indoles (tryptamines) in the presence of NaH.