174728-80-4

Upstream product

• 5840-67-5 4-Benzyloxy-phthalsaeure-dimethylester 
• 22479-95-4 dimethyl 4-hydroxyphthalate 
• 610-35-5 4-hydroxyphthalic acid 

Downstream Products

• 522609-31-0 4-benzyloxy-benzene-1,2-dicarbaldehyde 

Relevant academic research and scientific papers

A systematic study of peripherally multiple aromatic ester-functionalized poly(benzyl ether) dendrons for the fabrication of organogels: Structure-property relationships and thixotropic property

A new class of peripherally multiple aromatic ester-functionalized poly(benzyl ether) dendrons and/or dendrimers with different focal point substituents, surface groups, interior structures, as well as different generations have been synthesized and their structure-property relationships with respect to their gelation ability have been investigated systematically. Most of these dendrons are able to gel organic solvents over a wide polarity range. Evident dendritic effects were observed not only in gelation capability but also in thermotropic, morphological, and rheological characterizations. It was disclosed that subtle changes in peripheral ester functionalities and interior dendritic structures affected the gelation behavior of the dendrons significantly. Among all the dendrons studied, the second- and third-generation dendrons G0G2-Me and G0G3-Me with dimethyl isophthalates (DMIP) as peripheral groups exhibited the best capability in gelation, and stable gels were formed in more than 22 aromatic and polar organic solvents. The lowest critical gelation concentration (CGC) reached 2.0 mg mL-1, indicating that approximately 1.35×104 solvent molecules could be entrapped by one dendritic molecule. Further study on driving forces in gel formation was carried out by using a combination of single-crystal/powder X-ray diffraction (XRD) analysis and concentration- dependent (CD)/temperature-dependent (TD) 1H NMR spectroscopy. The results obtained from these experiments revealed that the multiple π-π stacking of extended π-systems due to the peripheral DMIP rings, cooperatively assisted by non-conventional hydrogen-bonding, is the key contributor in the formation of the highly ordered supramolecular and fibrillar network. In addition, these dendritic organogels exhibited unexpected thixotropic-responsive properties, which make them promising candidates with potential applications in the field of intelligent soft materials. s

Convenient syntheses of fluorous phenols of the formula triarylphosphites

The aldehydic benzyl ethers PhCH2OC6H4CHO (2; a/b = paralmeta series) are readily available from the corresponding phenols and react with Wittig reagents derived from [Ph3PCH2CH2Rf8]+- (Rf8 = (CF2)7CF3) to give PhCH2OC6H4CH=CHCH2Rf8 (86-93%, Z major). Reactions with H2 over Pd/C give the fluorous phenols HOC6H4(CH2)3Rf8 (4a,b; 87-91%). Condensations with PCl3 and NEt3 (3.0:1:0:3.3 mol ratio) give the flourous phosphites P[OC6H4(CH2)3Rf8] 3 (5a,b; 92-94%), but traces of 4a,b are difficult to remove. The phthalate-based benzyl ethers PhCH2OC6H3COOR 2 (7; c/d = 3,5/3,4 -OC6H3-3,n-(R)2 series) are easily accessed and reduced with LiAlH4 to the diols PhCH2OC6H3(CH2OH)2 (8c,d; 89-90%). Diol 8c and the Dess-Martin periodinane react to give the dialdehyde PhCH2OC6H3(CHO)2 (9C; 95%). This is elaborated by a sequence analogous to 2 → 4 → 5 to the flourous phenol HOC6H3((CH2)3Rf8) 2 (11c; 97%/96%, two steps) and phosphite P[OC6H3((CH2)3Rf8) 2]3 (12C, 92%), from which traces of 11c are difficult to remove. Diol 8d can be similarly elaborated to 11d, but the dialdehyde 9d is labile and combined yield of the Dess-Martin/Wittig steps is 32%. The CF3C6F11/ toluene partition coefficients of 11c,d, and 12c (two pony tails; 70:30,72:28, 92:8) are much higher than those of 4a and b (one pony tail; 12:88, 14:86).

Antiviral agent containing benzodithiin derivative as active ingredient

Antiviral agents comprising, as an active ingredient, a 1,4-dihydro-2,3-benzodithiin derivative of the formula STR1 wherein each symbol is as defined in the Specification, or a pharmacologically acceptable salt thereof. The antiviral agents of the present invention have superior antiviral activity and are effective for the preventive and therapeutic treatment of viral diseases caused typically by RS virus.