174733-13-2

Upstream product

• 836595-90-5 4-[(2'-chloroethyl)hydroxy]-N-boc-L-phenylalanine methyl ester 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 3978-80-1 Boc-Tyr-OH 

Downstream Products

• 174733-11-0 (S)-4-O-(2-chloroethyl)tyrosine hydrochloride 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS USEFUL FOR TREATMENT OF DISEASES MEDIATED BY HIF-1

Provided herein are compounds that are useful in treatment of diseases mediated by HIF-1.

Streptogramins for preparing same by mutasynthesis

The invention provides a method for preparing streptogramins using genetically-modified microorganisms to influence the biosynthesis of at least one of the precursors of the group B streptogramins. Cultures of the genetically-modified microorganisms are supplemented with a least one precursor that is different from the streptogramin precursor whose biosynthesis is altered and the streptogramins produced are recovered.