1748-99-8

Usage

Physical state

White solid

Solubility

Insoluble in water, soluble in organic solvents

Usage

Reagent in organic synthesis

Applications

Production of pharmaceuticals and other fine chemicals

Functional groups

Alcohol and aromatic functionalities

Versatility

Building block for various reactions

Pharmacological properties

Studied for potential antifungal and antibacterial activity

Industry relevance

Valuable and versatile compound in chemical and pharmaceutical industries

Upstream product

• 931-19-1 2-methylpyridine N-oxide 
• 119-61-9 benzophenone 
• 4377-33-7 2-chloromethylpyridine 
• 301547-16-0 (1R,2S)-1,7,7-trimethyl-2-(2-pyridinylmethyl)bicyclo[2.2.1]heptan-2-ol 
• 109-06-8 α-picoline 
• 81374-77-8 2-(1-Hydroxy-1,1-diphenylethyl)pyridine N-oxide 

Relevant academic research and scientific papers

Tuning the reducing properties of 1,2-diaryl-1,2-disodiumethanes

(Chemical Equation Presented) We investigated the reducing properties of a series of 1,2-diaryl-1,2-disodiumethanes by means of equilibration reactions. The electron-donor power of these vic-diorganometals is strongly affected by the nature of substituents present either on the aromatic ring(s) or on the carbanionic centers, and it can be correlated with their ability to delocalize the arylmethyl carbanions. These findings are supported by electrochemical analysis of the reduction behavior of the parent 1,2-diarylalkene. Applications of these results to the reduction of selected substrates are described. 2009 American Chemical Society.

Improved synthesis of C2-symmetrical pyridinediols and synthesis of C(s)-symmetrical pyridinediols

Base-induced reaction of 2,6-dimethylpyridine (2,6-lutidine) (1) with two equivalents of various ketones has been reported to provide C2-symmetrical pyridine diols 3. Closer examination reveals that competitive di-addition to a single methyl gr

DIPHENYLHYDROXYMETHYLATION OF 2-METHYLPYRIDINE N-OXIDE BY KETYLS AND DIANIONS OF BENZOPHENONE

In the reaction of 2-methylpyridine N-oxide with the lithium ketyl and the dianion of benzophenone the products from diphenylhydroxymethylation in the side chain, i.e., 2-(1-hydroxy-1,1-diphenylethyl)pyridine N-oxide, and in the ring, i.e., 2-methyl-6-(diphenylhydroxymethyl)pyridine N-oxide, are formed.The product from reductive diphenylhydroxymethylation in the methyl group, i.e., 2-(1-hydroxy-1,1-diphenylethyl)pyridine, is formed preferentially in the reactions with the ketyl and the dianion of benzophenone.The condensation with the sodium ketyl and the dianion of benzophenone takes place similarly and leads to significantly lower yields of the products.