174800-22-7Relevant articles and documents
Pyridyl imidazole derivatives and processes for the preparation thereof
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, (2008/06/13)
Novel pyridyl imidazole derivatives of formula(I) inhibit effectively the action of angiotensin II and have a superior antihypertensive activity: STR1 wherein: A is a straight, branched or cyclic C1 -C6 alkyl or alkenyl group, OR1 (wherein R1 is a hydrogen, or a straight, branched or cyclic C1 -C6 alkyl or alkenyl radical), or NR2 R3 (wherein R2 and R3 are independently a hydrogen, or a straight, branched or cyclic C1 -C6 alkyl radical); B is a group of the following formula STR2 D is a hydrogen; a halogen; a straight, branched or cyclic C1 -C6 alkyl, C2 -C6 alkenyl or C2 -C6 alkynyl group which is optionally substituted with OH, a C1 -C4 alkoxy radical, CO2 R1, COR1, CON(R1)2 or N(R1)2, wherein R1 is the same as defined above; tetrazol-5-yl; a perfluoro-C1 -C4 alkyl group; or N(R1)2, OR1, CO2 R1 or CON(R1)2, wherein R1 is the same as defined above; E is a hydrogen; a halogen; a straight or branched C1 -C6 alkyl, C2 -C6 alkenyl or C2 -C6 alkynyl group which is optionally substituted with OH, a C1 -C4 alkoxy radical, CO2 R1, COR1, CON(R1)2 or N(R1)2, wherein R1 is the same as defined above; a perfluoro-C1 -C4 alkyl group; NO2 ; or N(R1)2 or OR1, wherein R1 is the same as defined above; and n is 0 or an integer of 1 to 4.
