174810-05-0

Upstream product

• 4427-96-7 4-vinyl-1,3-dioxolan-2-one 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 127505-64-0 2-(S)-N-phthalimido-3-buten-1-yl benzyl ether 
• 91103-37-6 tert-butyl [(1S)-1-(hydroxymethyl)prop-2-en-1-yl]carbamate 
• 1315454-62-6 C₂₀H₂₁NO₆ 
• 1315454-61-5 (S)-2-(1-((4-methoxybenzyl)oxy)but-3-en-2-yl)isoindoline-1,3-dione 

Relevant academic research and scientific papers

Chiral β - substituted - α, β - unsaturated amino alcohol compound preparation method

The invention discloses a preparation method of a chiral beta-substituted-alpha, beta-unsaturated amino alcohol compound. In the presence of a solvent and a chiral catalyst of palladium, beta-substituted alpha, beta-unsaturated carbonic ester compound (I) performs asymmetric allylic substituted reaction in nitrogen atmosphere to generate chiral beta-substituted-alpha, beta-unsaturated amino alcohol (II). The preparation method of the invention has the advantages mild conditions and simple operation, and can realize good reaction yield and enantioselectivity; therefore, the invention has good application prospect.