174822-36-7Relevant academic research and scientific papers
Pushing the limits for Thiol-Ene and CuAAC reactions: Synthesis of a 6th generation dendrimer in a single day
Antoni, Per,Robb, Maxwell J.,Campos, Luis,Montanez, Maria,Hult, Anders,Malmstroem, Eva,Malkoch, Michael,Hawker, Craig J.
, p. 6625 - 6631 (2010)
Dendrimer synthesis should not be tedious and time-consuming. By utilizing an AB2-CD2 approach and having orthogonal, "clickable" groups on each monomer, the time for dendrimer assembly can be drastically reduced. This was shown by preparation of a sixth generation dendrimer from starting monomer units in a single day.
Soft hydrogels from tetra-functional PEGs using UV-induced thiol-ene coupling chemistry: A structure-to-property study
Olofsson, Kristina,Malkoch, Michael,Hult, Anders
, p. 30118 - 30128 (2014)
In this work, photo-induced thiol-ene coupling (TEC) was used to produce well-defined poly(ethylene glycol) (PEG)-based hydrogels. PEGs of four different molecular weights (2k, 6k, 10k, and 20k) were functionalized with G1-allyl dendrons using anhydride chemistry to produce tetra-functional TEC crosslinkable PEGs. The tetra-functional PEGs were subsequently crosslinked with a tri-functional thiol in ethanol to form hydrogels. The synthesized hydrogels were characterized with respect to swelling behaviour, rheological properties and hydrolytic degradation. It was found that the molecular weight of the PEG chain greatly influences the final properties of the hydrogel, where a higher molecular weight of PEG gives an increased weight swelling ratio from 240% for PEG-2k hydrogels to 1400% for PEG-20k hydrogels, as well as decreased elastic moduli, with Young's moduli ranging from 106 MPa to 6 MPa, for PEG-2k and PEG-20k hydrogels, respectively. It was also found that the hydrolytic stability in alkaline conditions (pH 10) decreased when the molecular weight of PEG in the hydrogels increased. the Partner Organisations 2014.
SOLVENT-LESS IONIC LIQUID EPOXY RESIN
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Page/Page column 17; 18, (2018/05/17)
Solvent free epoxy system that includes: a hardener compound H comprising: a molecular structure (Y1-R1-Y2), wherein R1 is an ionic moiety Y1 is a nucleophilic group and Y2 nucleophilic gro
LINKER COMPOUNDS, METHODS OF PRODUCING THE SAME AND USES THEREOF
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Page/Page column 22-23, (2018/10/19)
The present disclosure provides a bifunctional linker for coupling at least one functional moiety, preferably a bis-allyl propionic acid (BAPA), to a polymer-containing matrix. Also disclosed by the present disclosure are anhydrides of the bifunctional linker, processes for preparing the bifunctional linker and such anhydride, as well as surfaces, such as cellulose containing matrices, coupled with the bifunctional linker, at times, the latter carrying a functional agent.
Accelerated growth of dendrimers via thiol-ene and esterification reactions
Montanez, Maria I.,Campos, Luis M.,Antoni, Per,Hed, Yvonne,Walter, Marie V.,Krull, Brandon T.,Khan, Anzar,Hult, Anders,Hawker, Craig J.,Malkoch, Michael
experimental part, p. 6004 - 6013 (2011/11/12)
By taking advantage of the orthogonal nature of thiol-ene coupling and anhydride based esterification reactions, a facile and chemoselective strategy to dendritic macromolecules has been developed. The ability to interchange growth steps based on thiol-ene and anhydride chemistry allows the synthesis of fifth-generation dendrimers in only five steps and under benign reaction conditions. In addition, the presented coupling chemistries eliminate the traditional need for protection/deprotection steps and afford dendrimers in high yield and purity. The modularity of this strategy coupled with the latent reactivity of the alkene/hydroxyl chain ends was demonstrated by using different cores (alkene and hydroxyl functional), various AB2 and CD 2 monomers and a range of chain end groups. As a result, three dendritic libraries were prepared which exhibited tunability of both the chemical functionality and physical properties including the fabrication of PEG hydrogels.
