174832-50-9Relevant academic research and scientific papers
A general synthesis of amines and hydrazines by oxidation of amidocuprates and zinc-amidocuprates
Cane,Brancaleoni,Dembech,Ricci,Seconi
, p. 545 - 548 (2007/10/03)
A wide range of amines and hydrazines were synthesized according to an electrophilic amination protocol by oxidative decomposition of readily generated lithium- and zinc-amidocyanocuprates. Optimization of the yields was achieved by the appropriate combination of the organometallic cluster and the nature of the oxidizing agent.
Oxidative intramolecular coupling of amidocuprates as a novel route to amines and hydrazines
Alberti, Angelo,Cane, Francesco,Dembech, Pasquale,Lazzari, Dario,Ricci, Alfredo,Seconi, Giancarlo
, p. 1677 - 1681 (2007/10/03)
Amidocuprates, derived from organocopper reagents and lithium amides upon exposure to oxygen at low temperature, provide new amine derivatives in satisfactory yields. Details of this flexible and simple methodology are given. The reaction mechanism is analyzed in terms of an oxidative intramolecular coupling of aminyl radicals with the ligands on Cu in the intermediate amidocuprate. This reaction is a mild and efficient method for N-alkylation, -vinylation, and -arylation by which a number of amines, not easily accessible by normal routes, can be synthesized. Once applied to lithium hydrazides, it also provides a new and straightforward entry to N-substituted hydrazines.
