174842-80-9Relevant articles and documents
Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl-ester prodrugs of carboxylic acid agents
Iley, Jim,Moreira, Rui,Calheiros, Teresa,Mendes, Eduarda
, p. 1634 - 1639 (2007/10/03)
Purpose. Novel tertiary amidomethyl esters were synthesized and evaluated as potential prodrugs of carboxylic acid agents. Methods. The hydrolyses of the title compounds in buffer solutions and in plasma were studied by UV spectroscopy and HPLC. Results.