174844-93-0Relevant academic research and scientific papers
Preparation method of aromatic vinyl bromide derivative
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Paragraph 0058-0062, (2020/09/30)
The invention discloses a preparation method of an aromatic vinyl bromide derivative, and relates to a preparation method of an aromatic vinyl bromide derivative. The invention aims to solve the problems of harsh reaction conditions, poor substrate compatibility and environmental pollution in an existing method for synthesizing aromatic vinyl bromide derivatives. The method comprises the followingsteps: dissolving an alkyne derivative, a brominated aromatic ring compound and a catalyst in an organic solvent at the room temperature in a nitrogen atmosphere, carrying out an illumination reaction, carrying out rotary evaporation on the solvent after the reaction is finished, and purifying to obtain the product. The method solves the problems of low yield, poor environmentally friendly property and poor substrate compatibility caused by the fact that existing aromatic vinyl bromide derivative synthesis needs toxic and harmful substance excitation and a transition metal catalytic system, and is applied to the field of organic synthesis.
Convenient synthesis and cytokinin activity of β-substituted 4-styrylpyridines, the simplest cytokinin analogs with a moderate cell division-promoting activity
Nishikawa, Shiro,Sato, Masakazu,Kojima, Hisaki,Suzuki, Chi-E,Yamada, Nobuko,Inagaki, Minoru,Kashimura, Naoki,Mizuno, Hiroshi
, p. 1337 - 1342 (2007/10/03)
Designed synthesis of Z- and E-isomers of β-substituted 4-styrylpyridines as cytokinin analogs was conveniently achieved by nucleophilic and electrophilic addition of ethanol, methyl mercaptan, and hydrogen halides (HCl, HBr, and HI) to 4-(phenylethynyl)pyridine prepared by palladium-catalyzed coupling. They easily underwent E-Z photoisomerization under monochromatic UV light or sunlight. A tobacco callus assay revealed that the Z-isomers were more active than their E-isomers and that the Z-ethoxy derivative, which showed the highest activity among the β-substituted 4-styrylpyridines, was one-fifth as potent as kinetin. The Z-ethoxy derivative also promoted betacyanin biosynthesis of Amaranthus seedlings at 4-100 μM.
