17485-32-4

Upstream product

• 587-04-2 m-Chlorobenzaldehyde 
• 1004-00-8 4-chloro-2-aminobenzenethiol 
• 873-63-2 m-chlorobenzyl alcohol 
• 51774-43-7 3-chloro-N-methyl-N-phenylbenzamide 
• 69859-25-2 3-chloro-N-methyl-N-phenylbenzothioamide 
• 618-46-2 m-Chlorobenzoyl chloride 

Relevant academic research and scientific papers

Urea nitrate–catalyzed C-N and C-S bond formation: A mechanochemical approach for 5-chloro-2-arylbenzo[d]thiazole derivatives

A series of substituted 5-chloro-2-arylbenzo[d]thiazoles were synthesized using 4-chloro-2-aminothiophenol and aromatic aldehydes in the presence of urea nitrate as a catalyst using the mechanochemical grindstone technique. This protocol was effectively carried out under metal-free conditions at room temperature, and the desired products were obtained in high to excellent yields in short reaction time (30–60 s). The structure of all the synthesized derivatives was confirmed by spectral characterization. The designed protocol has several benefits like eco-friendly, solvent-free, high yields, easy workup, and recyclability of catalyst. The catalyst was reusable at least four times without significant loss of activity. The good functional group tolerance with a series of derivatives has been demonstrated.

Preparation method of heterogeneous sustainable catalytic benzothiazole derivatives (by machine translation)

The invention relates to a preparation method of a heterogeneous sustainable catalytic benzothiazole derivative. The chemical structural formula is that, the substituent R1 is any one of a substituted aryl group, a substituent position and a conjugation position, R2 is any one of an aromatic substituted aryl group, a substituent position and a conjugation position are not fixed. The synthesis method is characterized in that Cu-MOF derivative materials are added, reaction is carried out by O-aminophenol and benzyl alcohol by one-pot method, and the by-products are produced in the form of water. To the method, the catalyst can be separated and put into the next reaction after the reaction, and the catalytic effect remains unchanged. The catalyst Cu-MOF derived material is a catalyst obtained by carbonizing HKKKSUT-1. The reaction makes the reaction green more further. The utility model provides an efficient. The invention relates to a pollution-free synthesis method for benzothiazole derivatives. (by machine translation)

An efficient synthesis of benzothiazole using tetrabromomethane as a halogen bond donor catalyst

An efficient and mild protocol has been developed for the synthesis of 2-substituted benzothiazole under solvent- and metal-free conditions using CBr4 as the catalyst. This process involves the activation of a thioamide through halogen bond formation between the sulphur atom of the thioamide and bromine atom of the CBr4 molecule. The presence of halogen-bonding interaction between N-methylthioamides and tetrabromomethane has been demonstrated with several control experiments, spectroscopic analysis and density functional theory (DFT). This methodology has a wide substrate scope for the synthesis of both 2-alkyl and 2-aryl substituted benzothiazoles.

Unexpectedly Simple Synthesis of Benzazoles by tBuONa-Catalyzed Direct Aerobic Oxidative Cyclocondensation of o-Thio/Hydroxy/Aminoanilines with Alcohols under Air

tBuONa-catalyzed direct aerobic oxidative cyclocondensation reactions of readily available alcohols and o-thio/hydroxy/aminoanilines under air have been developed and provide an efficient, practical, and green method for the synthesis of benzazoles. Mechanistic studies revealed that o-substituted anilines promote the initial aerobic alcohol-oxidation step, which explains the high reactivity and success of this unexpectedly simple and practical cyclocondensation method. Simple and straight: tBuONa-catalyzed direct aerobic oxidative cyclocondensation reactions of readily available alcohols and o-thio/hydroxy/aminoanilines under air provide an efficient, practical, and green method for the synthesis of benzazole heterocycles (see scheme). Mechanistic studies revealed that o-substituted anilines promote the initial aerobic alcohol-oxidation step.

Ru(III)-catalyzed oxidative reaction in ionic liquid: An efficient and practical route to 2-substituted benzothiazoles and their hybrids with pyrimidine nucleoside

An efficient, practical and environmentally benign synthesis of 2-substituted benzothiazoles was developed through RuCl3-catalyzed oxidative condensation of 2-aminothiophenol with aldehyde in ionic liquid by using air as the oxidant. With this procedure, a series of 2-substituted benzothiazoles and benzothiazole/pyrimidine nucleoside hybrids with antimicrobial activities were efficiently prepared from easily accessible starting materials.