174866-35-4Relevant academic research and scientific papers
Synthesis of antitumor lycorines by intramolecular Diels-Alder reaction
Perez, Dolores,Bures, Gema,Guitian, Enrique,Castedo, Luis
, p. 1650 - 1654 (1996)
Pharmacologically interesting lycorines were obtained by a short, efficient method based on an intramolecular Diels-Alder reaction between an α-pyrone and an alkyne, followed by loss of CO2 in a retro Diels-Alder reaction. The cyclization precursors (pyrones 9) were obtained in good yields in two or three steps from the corresponding homophthalic acid or anhydride.
