174879-27-7Relevant articles and documents
Synthesis of Scyphostatin Analogues through Hypervalent Iodine-Mediated Phenol Dearomatization
El Assal, Mourad,Peixoto, Philippe A.,Coffinier, Romain,Garnier, Tony,Deffieux, Denis,Miqueu, Karinne,Sotiropoulos, Jean-Marc,Pouységu, Laurent,Quideau, Stéphane
, p. 11816 - 11828 (2017/11/24)
A concise synthesis of two scyphostatin analogues is achieved from readily available ortho-substituted phenols. Key features include an asymmetric and biomimetic hydroxylative phenol dearomatization (HPD) reaction promoted by a chiral salen-type bis(λ5-iodane) reagent, followed by an in situ regio- and diastereocontrolled epoxidation.