174885-99-5

Basic information

• Product Name: (2-AMINO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (2-AMINO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;tert-Butyl (2-aMino-2-phenylethyl)carbaMate;tert-butyl N-(2-amino-2-phenylethyl)carbamate
• CAS NO: 174885-99-5
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.31
• Mol File: 174885-99-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 375.2°C at 760 mmHg
• Flash Point: 180.7°C
• Appearance: /
• Density: 1.066g/cm³
• Vapor Pressure: 7.89E-06mmHg at 25°C
• Refractive Index: 1.524
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.29±0.46(Predicted)
• CAS DataBase Reference: (2-AMINO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-AMINO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(174885-99-5)
• EPA Substance Registry System: (2-AMINO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER(174885-99-5)

Safety Data

• Hazardous Substances Data: 174885-99-5(Hazardous Substances Data)

Usage

General Description

(2-AMINO-2-PHENYL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER, also known as tert-butyl (2-aminophenethyl)carbamate, is a chemical compound with the molecular formula C14H20N2O2. It is an ester derivative of carbamic acid and is often used as an intermediate in the synthesis of various pharmaceutical compounds. The compound has been found to exhibit antifungal and antibacterial properties, making it a potential candidate for the development of new therapeutic agents. Additionally, it has been studied for its potential use in the treatment of neurodegenerative diseases and as an anti-inflammatory agent. However, as with any chemical compound, proper handling and storage precautions should be taken to ensure safe use.

InChI:InChI=1/C13H20N2O2/c1-13(2,3)17-12(16)15-9-11(14)10-7-5-4-6-8-10/h4-8,11H,9,14H2,1-3H3,(H,15,16)

Upstream product

• 67341-07-5 tert-butyl N-(2-hydroxy-2-phenylethyl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7568-93-6 2-Amino-1-phenylethanol 
• 912762-45-9 C₁₃H₁₈N₂O₃ 
• 76477-26-4 (2-Oxo-2-phenylethyl)carbamic acid tert-butyl ester 
• 613-89-8 2-Aminoacetophenone 
• 70-11-1 α-bromoacetophenone 
• 943321-52-6 tert-butyl 2-(1,3-dioxoisoindolin-2-yl)-2-phenylethylcarbamate 

Downstream Products

• 943321-53-7 1,1-dimethylethyl (2-{[(5-bromo-2-thienyl)carbonyl]amino}-2-phenylethyl)carbamate 
• 1044851-72-0 1,1-dimethylethyl (2-{[(5-bromo-3-thienyl)carbonyl]amino}-2-phenylethyl)carbamate 
• 1386979-97-0 N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide 
• 1386980-06-8 N-(5-(2-amino-1-phenylethylcarbamoyl)-2-chlorophenyl)-2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide 
• 1386981-15-2 tert-butyl 2-(4-chloro-3-(2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate 
• 1386981-17-4 tert-butyl 2-(4-chloro-3-(2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate 
• 1386981-24-3 (1-{6-[5-(2-tert-butoxycarbonylamino-1-phenyl-ethylcarbamoyl)-2-chloro-phenylcarbamoyl]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl}-piperidin-4-yl)-carbamic acid tert-butyl ester 
• 1386979-70-9 2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid [5-(2-amino-1-phenyl-ethylcarbamoyl)-2-chloro-phenyl]-amide 
• 1386980-84-2 (2-{4-chloro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 1386981-07-2 tert-butyl 2-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate 
• 1386981-45-8 tert-butyl 2-(4-chloro-3-(7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate 
• 1386981-70-9 tert-butyl 2-(4-chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-2-phenylethylcarbamate 
• 1386398-53-3 N-{3-[6-(2-amino-1-phenyl-ethylamino)-pyridin-2-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}-cyclohexane-1,4-diamine hydrochloride 
• 1386399-47-8 (4-{3-[6-(2-tert-butoxycarbonylamino-1-phenyl-ethylamino)-pyridin-2-yl]-1-trityl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino}-cyclohexyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR

The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

PYRAZOLO PYRIMIDINES

Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.

CARBOXYLIC ACID ARYL AMIDES

Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer.