1749-24-2Relevant academic research and scientific papers
Hydrolysis kinetic studies of schiff bases derived from pyrrolic aldehydes in buffered aqueous ethanol and sulfuric acid solutions: Structural effects of substitutes
Bengharez, Zohra,El Bahri, Zineb,Mesli, Abderrezzak
, p. 404 - 414 (2013/07/05)
Two series of substituted N-pyrrolyl-2-methylene-aniline were synthesized and characterized to study their stability in a large domain of pH (0-14) and especially in the H0 domain (-4 to 0). The hydrolysis kinetics of the azomethine group was established in homogeneous media using a thermostated UV-vis spectrophotometer. The hydrolysis mechanism was investigated, and the experimental kinetic constants were calculated. Then, the pH-rate diagram profile was determined and the structural effect of substitutes on the kinetic constants was clarified and discussed.
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment
Kouznetsov, Vladímir V.,Vargas Méndez, Leonor Y.,Sortino, Maximiliano,Vásquez, Yelkaira,Gupta, Mahabir P.,Freile, Mónica,Enriz, Ricardo D.,Zacchino, Susana A.
, p. 794 - 809 (2008/09/17)
Diverse N-substituted anilines bearing hetaryl fragments were easily prepared from corresponding aldimines derived from commercially available aromatic aldehydes and anilines. 2-Furyl substituted anilines showed very good antifungal activities against dermatophytes, particularly against Trichophyton rubrum (MIC = 3.12-6.25 μg/mL). In addition, all active compounds, 45-47, 73, and 74, were tested for cytotoxic activities against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines with the NCI-anticancer-drug screen. The activity of amines described in this paper, along with the low toxicity of most of them, shows promise for the future development of non-toxic new antimycotic agents.
C,H bond activation of imino substituted heterocycles: Synthesis and crystal structure of [μ2-η3-( R) N-CH2-C=C-C(H) =C(H)-X ]Fe2( CO) 6 and the isomeric clusters [μ2-η3-(R)N-CH2-C=C-X-C(R′)=C(R″)]Fe2(CO)6
Imhof, Wolfgang
, p. 31 - 43 (2007/10/03)
The reaction of Fe2(CO)9 with heterocyclic imines derived from thiophene-2-carbaldehyde or N-methyl-pyrrole-2-carbaldehyde produces the dinuclear compounds [μ2-η3-(R)N-CH2-C=C-C(H)-X(H)-X]Fe2(CO)6 (R = Ph, C6H11, p-tBu-C6H4; X = S, NMe). The analogous reaction with imines of thiophene-3-carbaldehyde or indole-3-carbaldehyde yields the corresponding isomeric clusters [μ2-η3-(R)N-CH2-C=C-X-C(R′)=C(R″)Fe2(CO)6 (R = Ph, C6H11, R′ = R″ = H, X = S; R = Ph, p-tBu-C6H4, R′ = R″ = -C6H4-, X = NH). The reaction proceeds via activation of the C,H bond in β-position relative to the exocyclic C,N double bond of the imine ligands. A 1,3 hydrogen shift reaction then leads to the formation of a methylene group instead of the former imine carbon atom. So, the imine ligands are transformed into μ2-η3-enyl-amido ligands being coordinated to an Fe2(CO)6 moiety, which is confirmed by X-ray structure analyses of six compounds.
