1749-31-1

Upstream product

• 13722-65-1 2-(1-phenyl-ethyl)-[1,3,6,2]dioxazaborocane 

Downstream Products

• 515151-90-3 (+/-)-Dihydroxy-<1-phenyl-ethylperoxy>-boran 
• 145782-28-1 (E)-2-(1-phenylethylidene)-1-tosylpyrrolidine 
• 1108170-33-7 2-[(dimethylamino)methyl]-8-(1-phenylethyl)[1]benzothieno[3,2-d]pyrimidin-4(3H)-one 

Relevant academic research and scientific papers

SYNTHESIS OF BORONIC ESTERS AND BORONIC ACIDS USING GRIGNARD REAGENTS

Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be preformed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg°. When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0°C in about 1 hour to form a boronic acid compound.