17492-27-2Relevant academic research and scientific papers
Bifunctional boronic compound complexing reagents and complexes
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, (2008/06/13)
Reagents suitable for the modification of a bioactive species for the purpose of incorporating a bifunctional boronic compound complexing moiety for subsequent conjugation to a different (or the same) bioactive species having pendant phenylboronic acid moieties of General Formula 1, wherein group R is an electrophilic or nucleophilic moiety suitable for reaction of the putative bifunctional boronic compound complexing reagent with a bioactive species, wherein group R2 is selected from one of H and OH moieties, and wherein group R3 is selected from one of an alkyl and a methylene bearing an electronegative substituent. Group Z is a spacer selected from (CH2)n and CH2O(CH2CH2O)n2, wherein n is an integer of from 1 to 5, and wherein n2 is an integer of from 1 to 4. Each of group Z2 and Z3 is a spacer selected from CH2Ar, CH2CONHCH2Ar, CH2CONH(CH2)n3CO-NHCH2Ar, and (CH2)n4NHCO(CH2)n5CONHCH2Ar, wherein the group Ar represents the aromatic ring in the reagent of General Formula I to which the spacer Z2 or Z3 is appended, wherein n3 is an integer of from 1 to 5, wherein n4 is an integer selected from one of 2 and 3, and wherein n5 is an integer of from 1 to 4. Reaction of a reagent of General Formula I with a bioactive species affords a conjugate having pendant putative bifunctional boronic compound complexing moieties. (one or more) The conjugate may be further reacted with hydroxylamine (NH2OH) by amidation of the benzoic acid ester moiety to afford a class of bifunctional boronic compound complexing conjugate, e.g., conjugate with one or more pendant bifunctional boronic compound complexing moieties.
Boronic compound complexing reagents and highly stable complexes
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, (2008/06/13)
Boron compound complexing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula I and General Formula II may be used, after further reactions described herein, to complex with boronic compounds, such as phenylboronic acid or derivatives thereof. STR1
Boronic compound complexing reagents and highly stable complexes
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, (2008/06/13)
Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula CIII, General Formula CIV, and General Formula CVI. In one embodiment, the reagents of General Formula CIII may be used to produce, after condensation with a bioactive species (BAS), the reagent of General Formula CIV. The reagent of General Formula CIV may be used to form a complex with a boron compound, such as a complex shown in General Formula CVI. STR1
