174951-49-6

Basic information

• Product Name: (2S)-2'-fluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone
• Synonyms: (2S)-2'-fluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone
• CAS NO: 174951-49-6
• Molecular Weight: 252.286
• Mol File: 174951-49-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S)-2'-fluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2'-fluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone(174951-49-6)
• EPA Substance Registry System: (2S)-2'-fluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propiophenone(174951-49-6)

Safety Data

• Hazardous Substances Data: 174951-49-6(Hazardous Substances Data)

Upstream product

• 1072-85-1 o-fluorobromobenzene 
• 135206-86-9 4-<(2S)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propionyl>morpholine 

Downstream Products

• 174563-15-6 (S)-1-(2-Fluorophenyl)-2-hydroxypropanone 
• 174563-27-0 1-<(1R,2S)-2-(2-fluorophenyl)-2-hydroxy-3-methanesulfonyloxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone 
• 174563-03-2 1-[(1R,2S)-2-(2-fluorophenyl)-2-hydroxy-3-(isopropoxydimethylsilyl)-1-methylpropyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2(1H,3H)-imidazolone 
• 174563-05-4 1-[(1R,2S)-2-(2-fluorophenyl)-2-hydroxy-3-(isopropoxydimethylsilyl)-1-methylpropyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2(1H,3H)-imidazolone 
• 174563-24-7 1-[(1R,2S)-2-(2-fluorophenyl)-2-hydroxy-3-methanesulfonyloxy-1-methylpropyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2(1H,3H)-imidazolone 
• 170910-92-6 1-[(1R,2R)-2-(2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2(1H,3H)-imidazolone 
• 174563-07-6 1-<(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2-imidazolidinone 
• 170910-90-4 1-[(1R,2R)-2-(2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2(1H,3H)-imidazolone 
• 174563-26-9 1-[(1R,2S)-2-(2-fluorophenyl)-2-hydroxy-3-methanesulfonyloxy-1-methylpropyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2(1H,3H)-imidazolone 
• 174563-04-3 1-[(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2(1H,3H)-imidazolone 
• 174563-06-5 1-[(1R,2S)-2-(2-fluorophenyl)-2,3-dihydroxy-1-methylpropyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2(1H,3H)-imidazolone 
• 174563-23-6 1-[(1R)-2-(2-fluorophenyl)-2-oxo-1-methylethyl]-3-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2(1H,3H)-imidazolone 
• 174563-25-8 1-[(1R)-2-(2-fluorophenyl)-2-oxo-1-methylethyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2(1H,3H)-imidazolone 
• 174563-16-7 (2S)-2'-fluoro-2-trifluoromethanesulfonyloxypropiophenone 

Relevant articles and documents

Optically active antifungal axoles. V. Synthesis and antifungal activity of stereoisomers of 3-Azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols

The (2S,3S)-, (2R,3S)- and (2S,3R)-stereoisomers of (2R,3R)-3-azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols [(2R,3R)-1a-d] were prepared and evaluated for antifungal activity against Candida albicans in vitro and in vivo to clarify th

Production of optically active triazole compounds and their intermediates

A compound of the formula (V): STR1 wherein Ar' is a halogenated phenyl group, R is a hydrocarbon residue having a functional group at the α-carbon, R3' is an optionally substituted aliphatic or aromatic hydrocarbon residue or an optionally substituted aromatic heterocyclic group, Y and Z are, the same or different, a nitrogen atom or a methine group optionally substituted with a lower alkyl group, and (R) and (S) represent configurations, which is an optically active intermediate for production of optically active triazole compounds (I): STR2 wherein the symbols have the same meanings as defined above, and methods of preparing the compounds (V) and (I).