174959-91-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 2549-93-1 1,4-bis-(aminomethyl)cyclohexane 
• 736054-16-3 [4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-carbamic acid tert-butyl ester 

Downstream Products

• 192323-13-0 trans-{4-[(Naphthalene-1-sulfonylamino)-methyl]cyclohexylmethyl}-carbamicacid tert-butyl ester 
• 910815-18-8 (4-{[5-carbamoyl-2-(2-chloro-benzylamino)-1-oxy-pyridin-4-ylamino]-methyl}-cyclohexylmethyl)-carbamic acid tert-butyl ester 
• 1412438-68-6 ethyl 3-{3-[({5-cyano-4-[({4-[(tert-butoxycarbonylamino)methyl]cyclohexyl}methyl)amino]pyrimidin-2-yl}amino)methyl]-2-methylphenyl}benzoate 

Relevant academic research and scientific papers

Heterocyclic Compounds

This invention relates to heterocyclic compounds of the formulas shown in the specification. It also relates to methods for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, and tissue injuries with one of the hete

Pyrimidine derivatives useful as inhibitors of PKC-theta

Disclosed are novel compounds of formula (I): wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

2,4-DIAMINOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA

Disclosed are novel compounds of formula (I) wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders and processes for preparing these compounds.

COMPOSITIONS AND METHODS FOR TREATING MAST-CELL MEDIATED CONDITIONS

The present invention describes compounds, methods and compositions effective to treat mast cell mediated inflammatory conditions, such as conjunctivitis, asthma and allergic rhinitis. The compounds of the invention comprise novel mono-and di-aminomethylb