17496-93-4

Usage

InChI:InChI=1/C6H12N2O/c1-6(2)3-7-5(9)8-4-6/h3-4H2,1-2H3,(H2,7,8,9)

Upstream product

• 7328-91-8 2,2-Dimethyl-1,3-diaminopropane 
• 57-13-6 urea 
• 105-58-8 Diethyl carbonate 
• 29559-55-5 1,3-dichloro-2,2-dimethylpropane 
• 82175-38-0 5,5-dimethyltetrahydro-2(1H)-pyrimidinethione 
• 201230-82-2 carbon monoxide 
• 868-84-8 S,S-dimethyl dithiocarbonate 
• 100533-65-1 N,N'-(2,2-dimethyl-propanediyl)-bis-carbamic acid diethyl ester 

Relevant academic research and scientific papers

A process for synthesizing [...] (by machine translation)

The present invention provides a process for synthesizing [...], including 2-hydrazino -5,5-dimethyl -1, 4, 5, 6-Tetrahydropyrimidines, their production and use hydrochloric acid salt and 1,5-bis-(4-trifluoromethyl phenyl) - 1,4-pentadiene-3-ketone preparation, and the raw material to the two, to isopropanol or ethanol as the solvent, the role of the concentrated hydrochloric acid produces [...]. By changing the synthesis process of the present invention, the reaction efficiency is improved. 2-hydrazino -5,5-dimethyl -1, 4, 5, 6-Tetrahydropyrimidines, their production and use the yield of the hydrochloride salt from 78% to 90% or more. 1,5-double (4-trifluoromethyl phenyl) - 1,4-pentadiene-3-one of the from the literature reports the yield of 83% to 90% or more. (by machine translation)

Copper-catalyzed oxidative desulfurization-oxygenation of thiocarbonyl compounds using molecular oxygen: An efficient method for the preparation of oxygen isotopically labeled carbonyl compounds

A novel copper-catalyzed oxidative desulfurization reaction of thiocarbonyl compounds, using molecular oxygen as an oxidant and leading to formation of carbonyl compounds, has been developed, and the utility of the process is demonstrated by its application to the preparation of a carbonyl-18O labeled sialic acid derivative. The Royal Society of Chemistry.

Synthesis of carbamates and ureas using Zr(IV)-catalyzed exchange processes

Equation presented Zirconium(IV)-catalyzed exchange processes have been developed to prepare both carbamates and ureas from dialkyl arbonates and carbamates employing 2-hydroxypyridine (HYP) and 4-methyl-2-hydroxyquinoline (MeHYQ) as catalytic additives, respectively A microwave acceleration effect was observed in Zr(IV)-catalyzed carbamate-urea exchange.

Microwave-assisted preparation of cyclic ureas from diamines in the presence of ZnO

A MW-assisted direct synthesis of cyclic ureas has been developed that proceeds expeditiously in the presence of ZnO thus shortening its reaction time; the process also eliminates the formation of byproducts when compared to the traditional methods involving conventional heating. A microwave-assisted facile method for the preparation of various ureas, cyclic ureas, and urethanes has been developed that affords nearly quantitative yield of products at 120°C (150 W), 71 kPa within 10 min using ZnO as a catalyst. The enhanced selectivity in this reaction is attributed to the deployment of ZnO whose absence results in poor yield and the generation of byproducts.

Propylene ureas and process for their preparation

Urea derivatives of formula 1 for the hardening of hydroxyl group-containing polymers, wherein each of R1-R7is a hydrogen atom or a linear or branched C1-C4-alkyl group, preferably methyl, ethyl, n-propyl, isopropyl, n-butyl or isobutyl, R1-R7being identical or different, and R8is a linear or branched C1-C6-alkyl group, preferably methyl, ethyl, n-propyl, isopropyl, n-butyl or isobutyl. The compounds 1 are prepared by reacting a compound 2 wherein R9is a member selected from the group consisting of —CHO, —CH(OH)—OR8and —CH(OH)2with a urea derivative 3 optionally followed by etherification of the reaction product with an alcohol X—OH, wherein X is a linear or branched C1-C4-alkyl group.

Catalytic oxidative carbonylation of primary and secondary diamines to cyclic ureas. Optimization and substituent studies

W(CO)6-catalyzed oxidative carbonylation of 1,3-propanediamine to the corresponding urea has been examined under a variety of conditions. Following optimization, the Thorpe-Ingold effect on ring closure was studied using 2,2-dialkyl-1,3-propanediamines. For the 2,2-dimethyl- and 2,2-dibutyl-1,3-propanediamines, the yields were increased significantly as compared to that of the unsubstituted case. The eight-membered cyclic urea 5-butyl-5-ethyl-1,3-diazepan-2-one (5f) was formed in 38% yield, while only trace amounts of the cyclic urea were produced from the parent 1,5-pentanediamine. In a study of secondary diamines, yields from the carbonylation of N,N′-dialkyl-2,2-dimethyl-1,3-propanediamines were lower than those obtained from the primary diamines. The main byproducts from secondary diamines were tetrahydropyrimidine derivatives formed from a competitive reaction of the substrate with the oxidant and base.

Process for producing cyclic ureas

A process for producing a cyclic urea is provided. The process comprises reacting a diamine expressed by the formula (II) wherein R represents hydrogen atom or a lower alkyl group and R' represent dimethylene group, a lower alkyl group-substituted dimethylene group, trimethylene group, a lower alkyl group-substituted trimethylene group, tetramethylene group, a lower alkyl group-substituted tetramethylene group, but a case where R represents hydrogen atom and R' represent dimethylene group, a case where R represents hydrogen atom and R' represents a lower alkyl group-substituted dimethylene group and a case where R represent methyl group and R' represents dimethylene group are excluded, with phosgene in the presence of a dehydrochlorinating agent. In the process, the diamine is first converted to its hydrochloride, followed by reacting the hydrochloride with phosgene in water solvent while maintaining a pH of the reaction liquid in the range of 5.0 to 8.0 by said dehydrochlorinating agent to obtain a cyclic urea expressed by the formula (I) STR1 wherein R and R' are each as defined above.