174968-08-2

Upstream product

• 174968-11-7 (3S,4S)-4-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-4-(4-methoxy-benzyloxy)-3-methyl-butyric acid methyl ester 
• 174968-12-8 [(4S,5S)-5-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-5-(4-methoxy-benzyloxy)-4-methyl-2-oxo-pentyl]-phosphonic acid dimethyl ester 
• 596092-70-5 (E)-(S)-4-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-4-(4-methoxy-benzyloxy)-but-2-enoic acid methyl ester 
• 174968-09-3 (R)-((S)-2,2-Diethyl-[1,3]dioxolan-4-yl)-(4-methoxy-benzyloxy)-acetaldehyde 
• 174968-13-9 (E)-(1S,6S,7S)-1,7-Bis-((S)-2,2-diethyl-[1,3]dioxolan-4-yl)-1,7-bis-(4-methoxy-benzyloxy)-6-methyl-hept-2-en-4-one 

Downstream Products

• 174968-20-8 (E)-4-[(2S,3S,4S,6R,8S,9S,10S)-8-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3,9-bis-(4-methoxy-benzyloxy)-4,10-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-but-2-enoic acid ethyl ester 
• 174968-06-0 (E)-4-[(2S,3S,4S,6R,8S,9S,10S)-8-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3,9-bis-(4-methoxy-benzyloxy)-4,10-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-but-2-en-1-ol 
• 174968-15-1 2-[(2S,3S,4S,6R,8S,9S,10S)-8-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3,9-bis-(4-methoxy-benzyloxy)-4,10-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-ethanol 

Relevant academic research and scientific papers

Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge 5. A highly concise and efficient synthesis of the C37～C54 tricyclic JKL-ring part

A concise and efficient synthesis of C37～C54 tricyclic JKL-ring unit (2) of halichondrin B (1) utilizing C2-symmetric spiroketal derivative (5) as a synthetic key intermediate, easily provided from dimethyl L-(+)-tartrate,