17498-50-9

Basic information

• Product Name: L-Valine hydrochloride
• Synonyms: L-VALINE HYDROCHLORIDE SOLUTION;L-Valine hydrochloride;L-Valine solution hydrochloride;H-Val-OHHCl;(S)-2-AMino-3-Methylbutanoic acid hydrochloride
• CAS NO: 17498-50-9
• Molecular Formula: C₅H₁₁NO₂*ClH
• Molecular Weight: 153.61
• EINECS: 241-505-8
• Product Categories: Amino AcidsAnalytical Standards;Alphabetic;Amino Acids, Peptides and Proteins;Life Sciences Standards;V
• Mol File: 17498-50-9.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 213.6 °C at 760 mmHg
• Flash Point: 83 °C
• Appearance: /
• Vapor Pressure: 0.0633mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: L-Valine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine hydrochloride(17498-50-9)
• EPA Substance Registry System: L-Valine hydrochloride(17498-50-9)

Safety Data

• F: 10
• Hazardous Substances Data: 17498-50-9(Hazardous Substances Data)

Usage

General Description

L-Valine hydrochloride is a chemical compound that contains the amino acid L-Valine in combination with hydrochloric acid. It is an essential amino acid that cannot be produced by the human body and must be obtained through diet or supplementation. L-Valine is important for muscle growth and repair, as well as for maintaining nitrogen balance in the body. L-Valine hydrochloride is commonly used in the pharmaceutical and food industries as a nutritional supplement, and it may also have potential applications in the treatment of various health conditions. Overall, L-Valine hydrochloride plays a crucial role in supporting overall health and well-being.

InChI:InChI=1/C5H11NO2.ClH/c1-3(2)4(6)5(7)8;/h3-4H,6H2,1-2H3,(H,7,8);1H/t4-;/m0./s1

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 13734-41-3 t-Boc-L-valine 
• 108-95-2 phenol 
• 2409-52-1 diethylitaconate 
• 652157-19-2 1-isopropyl (2S,3S)-3-methyl-N-(trifluoroacetamido)homoserinate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 51803-69-1 methyl 2-((2S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)acetate 
• 16944-60-8 (2S)-isopropylpiperazine-3,6-dione 
• 75525-21-2 diacetyl-cyclo(L-Val-Gly) 
• 117049-08-8 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl<(tert-butoxycarbonyl)amino>bromoacetate 
• 437768-95-1 (S)-N⁽¹⁾-(p-methoxybenzyl)-6-isopropylpiperazine-2,5-dione 
• 852994-82-2 [(2S,5S)-N,N'-bis-(4-methoxybenzyl)-5-isopropyl-3,6-dioxopiperazin-2-yl]-phosphonic acid diethyl ester 
• 852994-81-1 (6S,3Z)-N,N'-bis-(4-methoxybenzyl)-3-isobutylidene-6-isopropyl-piperazine-2,5-dione 
• 852994-80-0 (6S,3E)-3-isobutylidene-6-isopropyl-1,4-bis-(4-methoxybenzyl)piperazine-2,5-dione 

Downstream Products

• 6306-54-3 N-phthaloyl L-valine 
• 24629-22-9 Bz-Gly-Val 
• 2754-02-1 N-(N-(1,1-dimethylethoxycarbonyl)-L-phenylalanyl)-L-valine methyl ester 
• 47507-41-5 (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-3-methylbutanoic acid 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 155225-25-5 N--(R)-serine methylester 
• 159858-07-8 N-Cbz-Val-Cit-4-aminobenzyl alcohol 

Relevant articles and documents

Biocatalytic synthesis of valaciclovir using commercial enzymes

Proof-of-concept has been demonstrated for the biocatalytic transformation of aciclovir into valaciclovir, attaining high conversions from a solid-to-solid biotransformation in l-valine methyl ester using various formulations of Subtilisin Carlsberg activated for use in organic solvent.

An enantioselective synthesis of (S)-4-fluorohistidine

We report a new synthesis of enantiomerically pure (S)-4-fluorohisitidine based on diastereoselective alkylation of MOM-protected 4-fluoro-5-bromomethyl imidazole using the Sch?llkopf bis-lactim amino acid synthesis. Improvements in procedures for preparation of key intermediates are also described. (S)-4-Fluorohisitidine prepared by this new method was identical in all respects to material prepared by previous procedures.

Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii

A macrocylic dodecapeptide, cycloforskamide, was isolated from the sea slug Pleurobranchus forskalii, collected off Ishigaki Island, Japan. Its planar structure was deduced by extensive NMR analyses and was further confirmed by MS/MS fragmentation analyses. Finally, the absolute configuration was determined by total hydrolysis and chiral-phase gas chromatographic analysis. This novel dodecapeptide contains three d-amino acids and three thiazoline heterocycles and exhibits cytotoxicity against murine leukemia P388 cells, with an IC 50 of 5.8 μM.

Isolation and structural determination of the antifouling diketopiperazines from marine-derived Streptomyces praecox 291-11

Marine derived actinomycetes constituting 185 strains were screened for their antifouling activity against the marine seaweed, Ulva pertusa, and fouling diatom, Navicula annexa. Strain 291-11 isolated from the seaweed, Undaria pinnatifida, rhizosphere showed the highest antifouling activity and was identified as Streptomyces praecox based on a 16S rDNA sequence analysis. Strain 291-11 was therefore named S. praecox 291-11. The antifouling compounds from S. praecox 291-11 were isolated, and their structures were analyzed. The chemical constituents representing the antifouling activity were identified as (6S,3S)-6-benzyl-3-methyl-2,5-diketopiperazine (bmDKP) and (6S,3S)-6-isobutyl-3- methyl-2,5-diketopiperazine (imDKP) by interpreting the nuclear magnetic resonance and high-resolution mass spectroscopy data. Approximately 4.8mg of bmDKP and 3.1 mg of imDKP were isolated from 1.2 g of the S. praecox 291-11 crude extract. Eight different compositions of culture media were investigated for culture, the TBFeC medium being best for bmDKP and TCGC being the optimum for imDKP production. Two compounds respectively showed a 17.7 and 21 therapeutic ratio (LC50/EC50) to inhibit zoospores, and two compounds respectively showed a 263 and 120.2 therapeutic ratio to inhibit diatoms.