1750-78-3

Basic information

• Product Name: 5-(2-methylphenyl)-1,3,4-oxadiazol-2-amine
• Synonyms: 5-(2-methylphenyl)-1,3,4-oxadiazol-2-amine;5-(2-methylphenyl)-1,3,4-oxadiazol-2-amine(SALTDATA: FREE);5-(o-Tolyl)-1,3,4-oxadiazol-2-aMine;[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]amine;1,3,4-OXADIAZOLE, 2-AMINO-5-(o-TOLYL)-;2-Amino-5-(o-tolyl)-1,3,4-oxadiazole
• CAS NO: 1750-78-3
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.19
• Mol File: 1750-78-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 346.5°C at 760 mmHg
• Flash Point: 163.4°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 5.72E-05mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: 5-(2-methylphenyl)-1,3,4-oxadiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-methylphenyl)-1,3,4-oxadiazol-2-amine(1750-78-3)
• EPA Substance Registry System: 5-(2-methylphenyl)-1,3,4-oxadiazol-2-amine(1750-78-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1750-78-3(Hazardous Substances Data)

Usage

General Description

The chemical compound 5-(2-methylphenyl)-1,3,4-oxadiazol-2-amine is an organic compound that belongs to the oxadiazole class of chemicals. It is a white to yellow crystalline powder with a molecular formula of C9H9N3O. 5-(2-methylphenyl)-1,3,4-oxadiazol-2-amine has potential applications in the pharmaceutical industry, particularly in the development of new drugs. Its unique structure and properties make it a valuable building block for the synthesis of various biologically active compounds. The presence of the oxadiazole group also makes it a desirable candidate for the development of novel antimicrobial, antifungal, and anticancer agents. Its chemical properties and potential applications make it an important target for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C9H9N3O/c1-6-4-2-3-5-7(6)8-11-12-9(10)13-8/h2-5H,1H3,(H2,10,12)

Upstream product

• 16269-44-6 2-(2-methylbenzylidene)hydrazine carboxamide 
• 529-20-4 2-methylphenyl aldehyde 
• 563-41-7 semicarbazide hydrochloride 
• 7658-80-2 2-methylbenzohydrazide 
• 7653-33-0 2-(2-methylbenzoyl)hydrazinecarbothioamide 
• 506-68-3 bromocyane 

Downstream Products

• 37423-10-2 N,N-dimethyl-N'-(5-o-tolyl-[1,3,4]oxadiazol-2-yl)-formamidine 
• 53297-63-5 6-(4-chloro-phenyl)-2-o-tolyl-[1,3,4]oxadiazolo[3,2-a][1,3,5]triazine-5,7-dione 

Relevant articles and documents

Synthesis, telomerase inhibitory and anticancer activity of new 2-phenyl-4H-chromone derivatives containing 1,3,4-oxadiazole moiety

Based on previous studies, 66 2-phenyl-4H-chromone derivatives containing amide and 1,3,4-oxadiazole moieties were prepared as potential telomerase inhibitors. The results showed most of the title compounds exhibited significantly inhibitory activity on telomerase. Among them, some compounds demonstrated the most potent telomerase inhibitory activity (IC50 50 = 6.41 μM). In addition, clear structure–activity relationships were summarised, indicating that the substitution of the methoxy group and the position, type and number of the substituents on the phenyl ring had significant effects on telomerase activity. Among them, compound A33 showed considerable inhibition against telomerase. Flow cytometric analysis showed that compound A33 could arrest MGC-803 cell cycle at G2/M phase and induce apoptosis in a concentration-dependent way. Meanwhile, Western blotting revealed that this compound could reduce the expression of dyskerin, which is a fragment of telomerase.

A green approach for the synthesis of biologically active heterocyclic compounds at the platinum electrode

In the present study, 2-amino-5-substituted-1,3,4-oxadiazoles (4a-k) have been synthesized by the electrochemical oxidation of semicarbazone (3a-k) using platinum anode at room temperature under controlled potential electrolysis in an undivided cell assem

A convenient synthesis of 5-substituted 2-amino-1,3,4-oxadiazoles from corresponding acylthiosemicarbazides using iodine and Oxone

A convenient methodology has been developed for the synthesis of substituted 2-amino-1,3,4-oxadiazoles from corresponding acylthiosemicarbazides using catalytic amount of iodine/KI in the presence of Oxone as a bulk oxidant. This offers the adv