1750-99-8

Upstream product

• 481-06-1 santonin 

Downstream Products

• 10067-18-2 yomogin 
• 64340-42-7 alloalantolactone 
• 113018-56-7 11β-phenylseleno-7α,8βH-eudesm-4-en-12,8-olide 
• 91914-36-2 11α-phenylseleno-7,8αH-eudesm-4-en-12,8-olide 
• 58964-72-0 3-oxo-11α-phenylseleno-7,8αH-eudesma-1,4-dien-12,8-olide 
• 116534-20-4 (11S)-6α-hydroxy-3-oxo-8α-(toluene-4-sulfonyloxy)-eudesma-1,4-dien-12-oic acid-lactone 
• 14804-52-5 (4S,5S)-3-desoxy-tetrahydro-l-α-santonine 
• 75887-54-6 artemotil 
• 95774-16-6 8α-t-butyldimethylsilyloxy-3-o-nitrophenylseleno-5,7αH,6,11βH-elem-1-en-6,12-olide 
• 95839-63-7 dehydrotemisin 
• 86948-62-1 8α-t-butyldimethylsilyloxy-2,3-di-o-nitrophenylseleno-5,7-αH,6,11βH-eleman-6,12-olide 
• 86948-63-2 (3S,3aS,4S,6S,7S,7aR)-4-(tert-Butyl-dimethyl-silanyloxy)-7-((S)-2-hydroxy-1-methyl-ethyl)-3,6-dimethyl-6-[2-(2-nitro-phenylselanyl)-ethyl]-hexahydro-benzofuran-2-one 
• 67151-76-2 (+)-temisin 
• 95759-29-8 melitensin 

Relevant academic research and scientific papers

Biotransformation of 6α-santonin and 1,2-dihydro-α-santonin by Acremonium chrysogenum PTCC 5271 and Rhizomucor pusillus PTCC 5134

Biotransformation of 6α-santonin (1) and 1,2-dihyro-α-santonin (2) by two fungal strains Acremoniumchrysogenum (Cephalosporium chrysogenum) and Rhizomucor pusillus has been investigated for the firsttime. After 8 days of incubation of 1 by A. chrysogenum, four known metabolites including 1,2-dihydro-α-santonin (2) (30%), 8α-hydroxyl-α-santonin (3) (22%), 15-hydroxy-α-santonin (4) (15%) and 4,5-dihydro-α-santonin (5) (10%) were obtained. Incubation of 1 by R. pusillus afforded two metabolites 2 (45%) and 3(20%). Biotransformation of 1,2-dihyro-α-santonin by A. chrysogenum produced tetrahydro-α-santonin(6) with 52% yield and tetrahydroartemisin (7) with 33% yield. By R. pusillus, the yields of 6 and 7 were32% and 21%, respectively. The structures of the products were identified on the basis of spectroscopic data.