175013-46-4

Usage

Uses

Used in Pharmaceutical Research:
(2R,3R,3aS)-2-[(tert-butyldiphenylsilyl)oxy]methyl3-hydroxy-2,3,3a,9a-tetrahydro-6H-furo[2’,3’:4,5]oxazole[3,2a]-pyrimidin-6-one is utilized as a research compound for exploring its potential biological activities and therapeutic effects. Its unique structure allows scientists to investigate its interactions with biological targets and evaluate its efficacy in treating various diseases.
Used in Drug Development:
In the pharmaceutical industry, (2R,3R,3aS)-2-[(tert-butyldiphenylsilyl)oxy]methyl3-hydroxy-2,3,3a,9a-tetrahydro-6H-furo[2’,3’:4,5]oxazole[3,2a]-pyrimidin-6-one serves as a lead compound for the development of new drugs. Its chiral configuration and functional groups can be further modified to optimize its pharmacological properties, such as potency, selectivity, and bioavailability, ultimately leading to the creation of novel therapeutic agents.

Upstream product

• 3736-77-4 2,2'-Anhydrouridine 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 214055-25-1 5'-O-(tert-butyldiphenylsilyl)-2'-N,3'-O-carbonyl-2'-deoxy-2'-<(2-tetrahydrofuranyl)oxyamino>uridine 
• 1244970-40-8 C₂₉H₃₈N₂O₇Si 
• 1244970-41-9 C₂₉H₃₈N₂O₇Si 
• 185022-16-6 C₅₅H₆₁N₃O₁₂Si 
• 1054654-90-8 C₃₃H₃₄N₄O₉Si 
• 185022-14-4 Phenethyl-carbamic acid (2R,3R,3aS,9aR)-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-oxo-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-yl ester 
• 175013-49-7 5'-O-(tert-butyldiphenylsilyl)-2'-N,3'-O-carbonyl-2'-deoxy-2'-(hydroxylamino)uridine 

Relevant academic research and scientific papers

Synthesis of a protected keto-lysidine analogue via improved preparation of arabino-isocytosine nucleosides

Anhydrouridines react with aliphatic amines to give N-alkyl isocytosines, but reported procedures often demand very long reaction times and can be low yielding, with narrow scope. A modified procedure for such reactions has been developed, using microwave

2'-Deoxy-2'-alkoxyaminouridines: Novel 2'-substituted uridines prepared by intramolecular nucleophilic ring opening of 2,2'-O-anhydrouridines

Natural and unnatural modified nucleosides and nucleotides play important roles in biology, medicine, and as biomedical research tools. Reported herein is an application of synthetic methodology developed for the stereo- and regiospecific introduction of structural modifications at the 2'-position of uridine nucleosides. A novel class of modified nucleosides, 2'-alkoxylamino-2'-deoxy uridines, are prepared by intramolecular nucleophilic addition of a 3'-tethered alkoxycarbamate nucleophile to the 2'-position with concomitant opening of a 2,2'-anhydrouridine.