175029-76-2

Upstream product

• 908093-98-1 diazodiphenylmethane 
• 161914-33-6 (4aS,6aR,6bR,8aR,10S,12aR,12bR,14bS)-6a-Acetoxymethyl-10-hydroxy-2,2,6b,9,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid 

Downstream Products

• 175029-77-3 (4aS,6aR,6bR,8aR,10S,12aR,12bR,14bS)-6a-Acetoxymethyl-2,2,6b,9,9,12a-hexamethyl-10-phenoxythiocarbonyloxy-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid benzhydryl ester 
• 175029-78-4 (4aS,6aR,6bR,8aS,12aS,12bR,14bS)-6a-Acetoxymethyl-2,2,6b,9,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Endothelin receptor antagonist triterpenoid, myriceric acid A, isolated from Myrica cerifera, and structure activity relationships of its derivatives

As the first non-peptide endothelin receptor antagonist from a higher plant, a new triterpenoid, myriceric acid A (50-235) (1) was isolated from the bayberry, Myrica cerifera. Myriceric acid A (1) inhibited not only an endothelin-1-induced increase in cytosolic free Ca2+ concentration (IC50 = 11 ± 2 nM) but [125I]endothelin-1 binding in rat aortic smooth muscle cells (K(i)=66 ±15 nM). Two new related triterpenoids, myriceric acid C (6), and myriceric acid D (8), were also isolated. Furthermore, the chemical modification of these natural products led to the synthesis of sulfated derivatives (13, 14, 15) which showed 1.5 to 20 times higher affinity for endothelin receptors. The structure activity relationships of myriceric acids and their derivatives are discussed.