17510-80-4Relevant academic research and scientific papers
Pyrimidine derivatives, and preparation method and use thereof
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Paragraph 0101; 0102; 0103; 0104, (2016/10/08)
Pyrimidine derivatives disclosed in the invention respectively contain an aromatic five-membered heterocycle, a lone electron pair on a hetero atom S, O or N and an unsaturated five-membered ring form a conjugated system, and the lone electron pair effect of above hetero atoms has an inhibition effect on vascular endothelial growth factor (VEGF) receptors VEGFR-1, VEGFR-2 and VEGFR-3, so the pyrimidine derivatives are very good kinase inhibitors. The pyrimidine derivatives have stronger VEGFR-1, VEGFR-2 and VEGFR-3 inhibition activity than pazopanib in the prior art, and can be used treat VEGF signal pathway inhibition diseases, such as lung cancer, kidney cell cancer and other solid tumors.
