175134-34-6

Basic information

• Product Name: Benzeneacetic acid, a-hydroxy-2-fluoro-, (S)-
• Synonyms: Benzeneacetic acid, a-hydroxy-2-fluoro-, (S)-;(S)-2-(2-Fluorophenyl)-2-hydroxyacetic acid
• CAS NO: 175134-34-6
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.1377832
• Mol File: 175134-34-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzeneacetic acid, a-hydroxy-2-fluoro-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-hydroxy-2-fluoro-, (S)-(175134-34-6)
• EPA Substance Registry System: Benzeneacetic acid, a-hydroxy-2-fluoro-, (S)-(175134-34-6)

Safety Data

• Hazardous Substances Data: 175134-34-6(Hazardous Substances Data)

Upstream product

• 79477-86-4 2-fluorophenylglyoxylic acid 
• 445-27-2 2'-Fluoroacetophenone 
• 389-31-1 2-fluoromandelic acid 
• 394-46-7 2-fluorostyrene 
• 485759-27-1 (S)-2-hydroxy-2-(2-fluorophenyl)acetonitrile 
• 108-05-4 vinyl acetate 
• 74-90-8 hydrogen cyanide 
• 446-52-6 2-Fluorobenzaldehyde 

Relevant articles and documents

The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).

Production Of Enantiopure alpha-Hydroxy Carboxylic Acids From Alkenes By Cascade Biocatalysis

The invention provides compositions comprising an alkene epoxidase and a selective epoxide hydrolase, such as a recombinant microorganism comprising a first heterologous nucleic acid encoding an alkene epoxidase and a second heterologous nucleic acid encoding a selective epoxide hydrolase. Exemplary alkene epoxidases include StyAB, while exemplary selective epoxide hydrolases include epoxide hydrolases from Sphingomonas, Solanum tuberosum, or Aspergillus. The invention also provides non-toxic methods of making enantiomerically pure vicinal diols or enantiomerically pure alpha-hydroxy carboxylic acids using these compositions and microorganisms.

Robust enzymatic resolution of 3-fluoromandelic acid with lipase PS supported on celite

The resolution of different mandelic acids using the lipase PS Amano SD enzyme is described. By supporting the lyophilized enzyme over Celite, both the activity and the stability of lipase PS in organic media were significantly improved, enabling the robust resolution scale-up of 3-fluoromandelic acid. The methodology was extended to produce a range of optically pure (R)-mandelic acids, avoiding tedious extractions or chromatography.