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ETHYL 1-(2,4-DIFLUOROPHENYL)-5-METHYLPYRAZOLE-4-CARBOXYLATE is a pyrazole derivative chemical compound characterized by the presence of an ethyl ester, a carboxylic acid, fluoro-substituted phenyl, and methyl groups. Its complex structure endows it with potential biological activity and pesticidal properties, making it a candidate of interest for pharmaceutical and agrochemical applications. Additionally, its unique chemical composition is valuable for research in organic synthesis and medicinal chemistry.

175135-71-4

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175135-71-4 Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 1-(2,4-DIFLUOROPHENYL)-5-METHYLPYRAZOLE-4-CARBOXYLATE is used as a pharmaceutical intermediate for its potential to contribute to the development of new drugs. Its structural features may enhance biological activity, making it a promising candidate for the treatment of various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 1-(2,4-DIFLUOROPHENYL)-5-METHYLPYRAZOLE-4-CARBOXYLATE is utilized as a precursor in the synthesis of pesticides. Its specific chemical structure may confer pesticidal properties, offering a new avenue for the development of effective and environmentally friendly pest control agents.
Used in Research and Development:
ETHYL 1-(2,4-DIFLUOROPHENYL)-5-METHYLPYRAZOLE-4-CARBOXYLATE is employed as a research compound in the fields of organic synthesis and medicinal chemistry. Understanding its properties and potential applications can provide valuable insights for the advancement of scientific knowledge and the creation of innovative chemical entities.

Check Digit Verification of cas no

The CAS Registry Mumber 175135-71-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,1,3 and 5 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 175135-71:
(8*1)+(7*7)+(6*5)+(5*1)+(4*3)+(3*5)+(2*7)+(1*1)=134
134 % 10 = 4
So 175135-71-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H9Cl2FN4O/c1-17(15)9-5-16-18(11(19)10(9)13)6-2-3-8(14)7(12)4-6/h2-5H,15H2,1H3

175135-71-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ETHYL 1-(2,4-DIFLUOROPHENYL)-5-METHYLPYRAZOLE-4-CARBOXYLATE

1.2 Other means of identification

Product number -
Other names HMS546L02

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:175135-71-4 SDS

175135-71-4Relevant articles and documents

Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation

Yang, Wei,Li, Yingjun,Ai, Yong,Obianom, Obinna N.,Guo, Dong,Yang, Hong,Sakamuru, Srilatha,Xia, Menghang,Shu, Yan,Xue, Fengtian

, p. 11151 - 11164 (2019/12/27)

Dysregulation of the Wnt/β-catenin signaling pathway has been widely recognized as a pathogenic mechanism for colorectal cancer (CRC). Although numerous Wnt inhibitors have been developed, they commonly suffer from toxicity and unintended effects. Moreover, concerns have been raised in targeting this pathway because of its critical roles in maintaining stem cells and regenerating tissues and organs. On the basis of the anthelmintic drug pyrvinium and previous lead FX1128, we have developed a compound YW2065 (1c) which demonstrated excellent anti-CRC effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity. The anti-CRC effect of YW2065 was highlighted by its promising efficacy in a mice xenograft model.

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