175135-74-7

Basic information

• Product Name: 3-Chloro-4-fluorophenylhydrazine hydrochloride
• Synonyms: LABOTEST-BB LT01147590;1-(3-chloro-4-fluorophenyl)hydrazine hydrochloride;3-CHLORO-4-FLUOROPHENYLHYDRAZINE HYDROCHLORIDE;3-Chloro-4-fluorophenylhydrazine hydrochloride, 98;3-Chloro-4-fluorophenylhydrazineHCl;3-Chloro-4-fluorophenylhydrazine hydrochloride 97%;3-Chloro-4-fluorophenylhydrazinehydrochloride97%;1-(3-chloro-4-fluorophenyl)hydrazine hydrochloride hydrate
• CAS NO: 175135-74-7
• Molecular Formula: C6H7Cl2FN2
• Molecular Weight: 197.04
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Phenylhydrazine;API intermediates
• Mol File: 175135-74-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 211 °C
• Boiling Point: 253.1 °C at 760 mmHg
• Flash Point: 106.9 °C
• Appearance: /
• Vapor Pressure: 0.0187mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: 3-Chloro-4-fluorophenylhydrazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-fluorophenylhydrazine hydrochloride(175135-74-7)
• EPA Substance Registry System: 3-Chloro-4-fluorophenylhydrazine hydrochloride(175135-74-7)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25
• Hazardous Substances Data: 175135-74-7(Hazardous Substances Data)

Usage

Uses

3-Chloro-4-fluorophenylhydrazine Hydrochloride is used to prepare 1,5- and 1,3-diaryl substituted pyrazoles as potential antimalarials targeting the enoyl-ACP reductase of Plasmodium falciparum.

InChI:InChI=1/C6H6ClFN2.ClH/c7-5-3-4(10-9)1-2-6(5)8;/h1-3,10H,9H2;1H

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 

Downstream Products

• 1049806-21-4 isopropyl (6-chloro-5-fluoro-2-methyl-1-(3-trifluoromethylbenzyl)-1H-indol-3-yl)acetate 
• 1254713-64-8 (3-tert-butyl-1-(3-chloro-4-fluorophenyl)-1H-pyrazol-5-yl)methanamine 
• 1255040-43-7 N-((3-tert-butyl-1-(3-chloro-4-fluorophenyl)-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-(methylsulphonamido)phenyl)propanamide 
• 1001522-07-1 5-tert-butyl-2-(3-chloro-4-fluorophenyl)pyrazol-3-amine 

Relevant articles and documents

Indole derivative and medical application thereof

The invention discloses an indole compound with FABP4/5 inhibitory activity and a preparation method and medical application of the indole compound. The indole compound is a compound of which the structural formula is shown as a formula I, and pharmaceutically acceptable salt or ester or solvate of the compound. The compound shown in the formula I is a novel FABP4/5 inhibitor and can be used for preparing medicines for preventing or treating FABP4/5 related diseases.

Design, synthesis and pharmacological evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives as potential antitumor agents

Two series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 2,4-imidazolinedione/pyrazolone scaffold were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against HT-29, H460, A549, MKN-45, and U87MG cancer cell lines in vitro. The pharmacological data indicated that most of the tested compounds showed moderate to significant cytotoxicity and high selectivity against HT-29, H460 and A549 cancer cell lines as compared with foretinib. The SAR analyses indicated that compounds with halogen groups, especially trifluoromethyl groups at 2-position on the phenyl ring (moiety B) were more effective. In this study, a promising compound 17 (c-Met IC50= 2.20 nM, a multi-target tyrosine kinase inhibitor) showed the most potent antitumor activities with IC50values of 0.14 μM, 0.18 μM, 0.09 μM, 0.03 μM, and 1.06 μM against HT-29, H460, A549, MKN-45, and U87MG cell lines, respectively.