175136-95-5Relevant articles and documents
Diethylamine: A smart organocatalyst in eco-safe and diastereoselective synthesis of medicinally privileged 2-amino-4H-chromenes at ambient temperature
Kulkarni, Makarand A.,Pandit, Kapil S.,Desai, Uday V.,Lad, Uday P.,Wadgaonkar, Prakash P.
, p. 689 - 695 (2013)
Diethylamine has been demonstrated to be an efficient organocatalyst in the diastereoselective synthesis of Bcl-2 protein antagonist (HA-14-1) and of its structural analogues by one-pot condensation between salicylaldehyde and three different C-H acids, viz. ethyl cyanoacetate, phenylsulfonyl acetonitrile, and malononitrile. Easy commercial availability of the catalyst at extremely low cost and avoidance of conventional work-up as well as purification procedures qualifies this scalable protocol for a "near-ideal synthesis".
Visible light induced, catalyst free, convenient synthesis of chromene nucleus and its derivatives using water-ethanol mixture as a solvent
Yadav, Snehlata,Srivastava, Madhulika,Rai, Pratibha,Singh, Jaya,Tiwari, Kamla Prasad,Singh, Jagdamba
, p. 4556 - 4561 (2015)
A highly efficient, green, eco-friendly, one pot protocol has been demonstrated for the synthesis of 2-imino-2H-chromene-3-carbonitrile (3), 2-aminochromene (4) and chromeno(2,3-b)pyridines (5). The synthesis of the chromene nucleus has been carried out under visible light irradiation in a water-ethanol mixture at room temperature using salicylaldehyde and malononitrile in different proportions. The adopted method shows significant advantages such as mild and clean reaction conditions, eco-friendly procedures, absence of catalysts and a short reaction time. This protocol involves the use of CFL as the visible light source and shows high selectivity in the presence of a mixture of ethanol and water. The reaction proceeds with good to excellent yield.
Catalyst-free cascade synthesis of densely functionalized chromenes in water
Bhat, Subrahmanya Ishwar
, p. 2532 - 2536 (2019/10/02)
An expeditious and environmental friendly, general protocol has been developed for the synthesis of 2-amino-3-cyano-4H-chromenes via cascade Knoevenagel-Michael-intramolecular cyclization in water. Pure solid products were obtained by simple filtration technique. The aqueous catalyst-free reactions lead to high product yield at room temperature.