17515-77-4 Usage
Uses
Used in Pharmaceutical Industry:
2-(Bromomethyl)-5-(trifluoromethyl)furan is used as an intermediate for the preparation of tertiary sulfonamides, which serve as liver X receptor (LXR) antagonists. These LXR antagonists are important in the treatment of various metabolic disorders, such as dyslipidemia and atherosclerosis, by modulating the activity of liver X receptors and reducing the synthesis of cholesterol and triglycerides.
Additionally, 2-(Bromomethyl)-5-(trifluoromethyl)furan is utilized in the synthesis of hydantoin-based inhibitors of MMP13 (matrix metalloproteinase 13). These inhibitors have potential applications in the treatment of osteoarthritis, a degenerative joint disease characterized by the breakdown of cartilage and the underlying bone. By inhibiting MMP13, which is an enzyme involved in the degradation of cartilage, these compounds can help slow down the progression of osteoarthritis and alleviate associated pain and inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 17515-77-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,5,1 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 17515-77:
(7*1)+(6*7)+(5*5)+(4*1)+(3*5)+(2*7)+(1*7)=114
114 % 10 = 4
So 17515-77-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H15F6NO4S2/c1-25-12(22)11(3-4-26-2)21-27(23,24)10-6-8(13(15,16)17)5-9(7-10)14(18,19)20/h5-7,11,21H,3-4H2,1-2H3
17515-77-4Relevant academic research and scientific papers
AMINOETHANOL DERIVATIVES
-
Page/Page column 125, (2010/11/30)
The present invention provides a pharmaceutical agent having cholesteryl ester transfer protein inhibitory action and useful as a blood lipid lowering agent and the like. The present invention relates to a compound represented by the formula wherein Ar1 is an aromatic ring group optionally having substituents, Ar2 is an aromatic ring group having substituents, OR'' is an optionally protected hydroxyl group, R is an acyl group, R' is a hydrogen atom or a hydrocarbon group optionally having substituents, or a salt thereof, and a pharmaceutical composition containing a compound of the formula (I) or a salt thereof or a prodrug thereof.
