175152-85-9

Upstream product

• 99548-55-7 4-bromo-2-methyl-benzoic acid methyl ester 
• 171364-83-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene 
• 24067-17-2 4-nitrophenylboronic acid 

Downstream Products

• 1313579-76-8 (S)-methyl 3-methyl-2-(5-(4-nitrophenyl)-1-oxoisoindolin-2-yl)butanoate 
• 1313579-77-9 (S)-methyl 2-(5-(4-aminophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate 
• 1313579-78-0 (S)-methyl 2-(5-(4-(3-(4-fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate 
• 1313577-29-5 (S)-2-(5-(4-(3-(4-fluorophenyl)ureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid 
• 1313582-47-6 (S)-methyl 2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate 
• 1313577-45-5 (S)-2-(5-(4-(3-(2-fluorophenyl)thioureido)phenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid 
• 1313582-69-2 (S)-methyl 2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoate 
• 1313577-67-1 (S)-2-(5-(4-benzamidophenyl)-1-oxoisoindolin-2-yl)-3-methylbutanoic acid 
• 1313582-10-3 (S)-methyl 3-methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoate 
• 1313576-55-4 (S)-3-methyl-2-(1-oxo-6-(4-(phenylsulfonamido)phenyl)isoindolin-2-yl)butanoic acid 

Relevant academic research and scientific papers

INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE

The present invention relates to heterocyclic compounds in all their stereoisomeric and tautomeric forms; and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable polymorphs. The invention also relates to processes for the manufacture of the heterocyclic compounds and to pharmaceutical compositions containing them. The said compounds and their pharmaceutical compositions are useful in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1. The present invention further provides a method of treatment of such diseases or disorders by administering a therapeutically effective amount of said compounds or their pharmaceutical compositions, to a mammal in need thereof.

PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY

This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.