175165-67-0Relevant articles and documents
Chiral synthesis of phosphodiesterase inhibitor, (R)-(-)-rolipram, by means of enantioselective deprotonation strategy
Honda, Toshio,Ishikawa, Fumihiro,Kanai, Kazuo,Sato, Shigeki,Kato, Daishiro,Tominaga, Hideo
, p. 109 - 112 (2007/10/02)
Enantioselective synthesis of the antidepressant (R)-(-)-rolipram (1) has been achieved by using an enantioselective deprotonation of the cyclobutanone derivative as a key step.