175202-25-2

Usage

Uses

Used in Biochemistry Research:
N-[4-(TRIFLUOROMETHYL)BENZOYL]-L-METHIONINE METHYL ESTER is used as a research tool for investigating the role of methionine in protein synthesis and function. Its unique structure allows scientists to explore the impact of methionine modifications on biological processes.
Used in Pharmaceutical Research:
In the pharmaceutical industry, N-[4-(TRIFLUOROMETHYL)BENZOYL]-L-METHIONINE METHYL ESTER is utilized in the design and synthesis of potential drug candidates. The trifluoromethyl group and the esterified methionine provide a platform for creating compounds with enhanced pharmacological properties and improved bioavailability, which are crucial for the development of effective medications.

InChI:InChI=1/C14H16F3NO3S/c1-21-13(20)11(7-8-22-2)18-12(19)9-3-5-10(6-4-9)14(15,16)17/h3-6,11H,7-8H2,1-2H3,(H,18,19)/t11-/m0/s1

Upstream product

• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 2491-18-1 (S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride 
• 402-43-7 p-trifluoromethylphenyl bromide 

Relevant academic research and scientific papers

Amide Synthesis by Nickel/Photoredox-Catalyzed Direct Carbamoylation of (Hetero)Aryl Bromides

Herein, we report a one-electron strategy for catalytic amide synthesis that enables the direct carbamoylation of (hetero)aryl bromides. This radical cross-coupling approach, which is based on the combination of nickel and photoredox catalysis, proceeds at ambient temperature and uses readily available dihydropyridines as precursors of carbamoyl radicals. The method's mild reaction conditions make it tolerant of sensitive-functional-group-containing substrates and allow the installation of an amide scaffold within biologically relevant heterocycles. In addition, we installed amide functionalities bearing electron-poor and sterically hindered amine moieties, which would be difficult to prepare with classical dehydrative condensation methods.

Single-Handed Helical Poly(quinoxaline-2,3-diyl)s Bearing Achiral 4-Aminopyrid-3-yl Pendants as Highly Enantioselective, Reusable Chiral Nucleophilic Organocatalysts in the Steglich Reaction

Helically chiral poly(quinoxaline-2,3-diyl)s bearing 4-aminopyrid-3-yl pendants were synthesized as new helical-polymer-based chiral nucleophilic organocatalysts. The obtained chiral nucleophilic polymer catalysts exhibited high catalytic activity, enantioselectivity, and reusability in asymmetric Steglich rearrangement of oxazolyl carbonate to C-carboxyazlactone. The polyquinoxaline-based, helically chiral DMAP catalyst mediated intramolecular acyl transfer selectively, by contrast with known small-molecule-based chiral organocatalysts, which also mediate intermolecular acyl transfers.