175203-64-2

Usage

Uses

Used in Pharmaceutical Research and Development:
3-[(1-BENZYL-4-PIPERIDYL)OXY]PROPANENITRILE is used as a research compound for its potential pharmacological properties, which are attributed to its unique structure and functional groups. It is of interest to researchers in the field of medicinal chemistry, who explore its applications in the development of new drugs.
Used as an Intermediate in Organic Synthesis:
In the chemical industry, 3-[(1-BENZYL-4-PIPERIDYL)OXY]PROPANENITRILE serves as an intermediate in the synthesis of various organic compounds. Its versatile structure allows it to be a valuable building block in the creation of a range of chemical products, including pharmaceuticals, agrochemicals, and other specialty chemicals.

InChI:InChI=1/C15H20N2O/c16-9-4-12-18-15-7-10-17(11-8-15)13-14-5-2-1-3-6-14/h1-3,5-6,15H,4,7-8,10-13H2

Upstream product

• 4727-72-4 1-benzyl-4-hydroxypiperidine 
• 107-13-1 acrylonitrile 
• 1005340-88-4 3-[(1-benzoylpiperidin-4-yl)oxy]propanenitrile 

Downstream Products

• 200868-41-3 3-(1-benzylpiperidine-4-yloxy)-propylamine 
• 242459-59-2 methyl 3-[(1-benzyl-4-piperidyl)oxy]propanoate 

Relevant academic research and scientific papers

Highly chemoselective metal-free reduction of tertiary amides

This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance. Copyright

New 1-benzyl-4-hydroxypiperidine derivatives as non-imidazole histamine H3 receptor antagonists

A series of 1-benzyl-4-(3-aminopropyloxy)piperidine and 1-benzyl-4-(5-aminopentyloxy)piperidine derivatives has been prepared. The 1-benzyl-4-hydroxypiperidine derivatives obtained were evaluated for their affinities at recombinant human histamine H3 receptor, stably expressed in HEK 293T cells. All compounds investigated show moderate to pronounced in-vitro affinities. The most potent antagonists in this series 9b2 (hH3R, pKi = 7.09), 9b1 (hH3R, pKi = 6.78), 9b5 (hH3R, pKi = 6.99), and 9b6 (hH3R, pKi = 6.97) were also tested in vitro as H3 receptor antagonists - the electrically evoked contraction of the guinea-pig jejunum. The histaminergic H1 antagonism of selected compounds 9b1, 9b2, and 9b4-9b6 was established on the isolated guinea-pig ileum by conventional methods; the pA2 values were compared with the potency of pyrilamine. The compounds did not show any H1 antagonistic activity (pA 2 2 = 9.53).

Heterocyclic compounds as inhibitors of rotomase enzymes

Compounds of the formula: wherein R1, Y, W, A and R2are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage.