175205-23-9Relevant articles and documents
Synthesis of methoxy-substituted chalcones and in vitro evaluation of their anticancer potential
Ethiraj, Kannatt Radhakrishnan,Aranjani, Jesil Mathew,Khan, Fazlur-Rahman Nawaz
, p. 732 - 742 (2014/01/06)
Methoxy-substituted chalcones, 3 were obtained using simple, efficient method from 2-naphtylethanone, 1 and aromatic aldehydes, 2. The in vitro cytotoxicity activities of the chalcones against a panel of three human cancer cell lines were explored. The tested compounds were found to possess significant cytotoxic activity. The DNA strand break and damage was quantified through alkaline comet assay, flow cytometric analysis, and chromatin condensation studies, which revealed the apoptotic nature of the compounds. Compound 3c, (3-(3,4,5-trimethoxyphenyl)-1-(2-naphthyl) prop-2-en-1-one) showed highest cytotoxicity of 0.019 μm against HeLa, 0.020 μm against HCT15 and 0.022 μm against A549. Compound 3e, (3-(3,5-dimethoxyphenyl)-1-(2-naphthyl) prop-2-en-1-one) showed better IC50 values against all the three cell lines employed for the study. Simple, highly efficient procedure from 2-naphtylethanone, 1 and aromatic aldehydes, 2 is reported. The in vitro cytotoxicity activity of the chalcones against a panel of three human cancer cell lines was explored. The tested compounds were found to possess significant cytotoxic activity. DNA stand break and damage was quantified by alkaline comet assay. Flow cytometric analysis and chromatin condensation studies revealed the apoptotic nature of the compounds.
