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4-Amino-2-(3-pyridyl)pyrimidine-5-carbonitrile, also known as Tofacitinib, is a chemical compound with the molecular formula C10H7N5. It is a small molecule inhibitor of Janus kinases (JAK), which plays a crucial role in the signaling pathways of various cytokines and growth factors involved in the immune response. Tofacitinib's ability to block the action of JAK enzymes helps reduce inflammation and control the autoimmune response in certain conditions.

175205-75-1

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175205-75-1 Usage

Uses

Used in Pharmaceutical Industry:
4-Amino-2-(3-pyridyl)pyrimidine-5-carbonitrile is used as an anti-inflammatory and immunosuppressive agent for the treatment of rheumatoid arthritis and ulcerative colitis. Its mechanism of action involves inhibiting JAK enzymes, which in turn reduces inflammation and modulates the immune response in these conditions.
Additionally, Tofacitinib is used as a potential treatment for other inflammatory and autoimmune diseases due to its ability to control the immune system and reduce inflammation. Its application in this context is based on the rationale that targeting JAK enzymes can help manage the underlying causes of these diseases by dampening the overactive immune response.

Check Digit Verification of cas no

The CAS Registry Mumber 175205-75-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,2,0 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 175205-75:
(8*1)+(7*7)+(6*5)+(5*2)+(4*0)+(3*5)+(2*7)+(1*5)=131
131 % 10 = 1
So 175205-75-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H7N5/c11-4-8-6-14-10(15-9(8)12)7-2-1-3-13-5-7/h1-3,5-6H,(H2,12,14,15)

175205-75-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Amino-2-(3-pyridyl)pyrimidine-5-carbonitrile

1.2 Other means of identification

Product number -
Other names 4-AMINO-5-CYANO-2-(PYRIDIN-3-YL)PYRIMIDINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:175205-75-1 SDS

175205-75-1Upstream product

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