175217-22-8

Basic information

• Product Name: 2-bromo-4,5-dimethylthiophene-3-carboxylic acid
• Synonyms: 2-bromo-4,5-dimethylthiophene-3-carboxylic acid;2-bromo-4,5-dimethyl-3-Thiophenecarboxylic acid
• CAS NO: 175217-22-8
• Molecular Formula: C₇H₇BrO₂S
• Molecular Weight: 235.09828
• Mol File: 175217-22-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-bromo-4,5-dimethylthiophene-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4,5-dimethylthiophene-3-carboxylic acid(175217-22-8)
• EPA Substance Registry System: 2-bromo-4,5-dimethylthiophene-3-carboxylic acid(175217-22-8)

Safety Data

• Hazardous Substances Data: 175217-22-8(Hazardous Substances Data)

Upstream product

• 19156-52-6 4,5-dimethylthiophene-3-carboxylic acid 
• 19156-44-6 ethyl 4,5-dimethylthiophene-3-carboxylate 
• 4815-24-1 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester 

Downstream Products

• 221060-73-7 2-bromo-N-(2-hydroxyphenyl)-4,5-dimethyl-3-thiophenecarboxamide 
• 175217-23-9 4,5-dimethyl-2-trimethylsilylthiophene-3-carboxylic acid 

Relevant articles and documents

Synthesis of thieno[2,3-b][1,5]benzoxazepine derivatives

A new series of 4-(4-methylpiperazin-1-yl)thieno[2,3-b][1,5]benzoxazepines 1a-k has been synthesized from 4-bromo-2-methylthiophene 6 or ethyl 2-amino-4,5-dimethyl-3-thiophencarboxylate 10. Preparation of the key intermediate thieno[2,3-b][1,5]benzoxazepine-4(5H)-ones 4a-i, 4k were carried out by treatment of 2-bromo-N-(2-hydroxyphenyl)-3-thiophencarboxamides 5a-i, 5k with potassium carbonate in DMSO. Compounds 1 are thienoanalogues of loxapine, a potent antipsychotic drug. Of these compounds, the neuroleptic activity of 2-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-b][1,5]benzoxazepine 1a (R1, R3=H, R2=CH3) demonstrated potent antipsychotic activity.