175226-81-0Relevant articles and documents
Benzyne-mediated trichloromethylation of chiral oxazolines
Huang, Xin,Zhao, Weizhao,Chen, De-Li,Zhan, Yaling,Zeng, Tingting,Jin, Huiquan,Peng, Bo
supporting information, p. 2070 - 2073 (2019/02/19)
A three-component reaction between benzyne, oxazolines and chloroform was developed for the synthesis of trichloromethylated chiral oxazolidines. Benzyne not only serves as an electrophile towards oxazolines but also acts as a base for the deprotonation of chloroform. The dual functions of benzyne enable the trichloromethylation of chiral oxazolines and thus construct chiral N,O-quaternary stereocenters.