175277-18-6

Basic information

• Product Name: 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE
• Synonyms: BUTTPARK 30\01-49;4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE;4-(TRIFLUOROMETHOXY)BENZOHYDRAZIDE;4-(Trifluoromethoxy)benzoic acid hydrazide 95%;4-(Trifluoromethoxy)benzoicacidhydrazide95%;4-(trifluoromethoxy)benzene-1-carbohydrazide;4-(Trifluoromethoxy)benzohydrazide, 4-(Trifluoromethoxy)benzenecarbohydrazide;4-Trifluoromethoxybenzhydrazide
• CAS NO: 175277-18-6
• Molecular Formula: C8H7F3N2O2
• Molecular Weight: 220.15
• Mol File: 175277-18-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 110 °C
• Appearance: /
• Density: 1.399g/cm³
• Refractive Index: 1.495
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.95±0.10(Predicted)
• CAS DataBase Reference: 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE(175277-18-6)
• EPA Substance Registry System: 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE(175277-18-6)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 175277-18-6(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethoxy)benzoic acid hydrazide is a chemical compound with the molecular formula C8H6F3NO2. It is a derivative of benzoic acid with a trifluoromethoxy group attached to the aromatic ring. 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE is commonly used in organic synthesis as a reagent for the preparation of various organic compounds. It can also be used as a precursor for the synthesis of pharmaceuticals and agrochemicals. Additionally, 4-(Trifluoromethoxy)benzoic acid hydrazide has potential applications in materials science, such as in the development of advanced polymers and functional materials. Due to its versatile reactivity and unique structural features, this chemical compound is of interest to researchers in various fields of chemistry and related disciplines.

InChI:InChI=1/C8H7F3N2O2/c9-8(10,11)15-6-3-1-5(2-4-6)7(14)13-12/h1-4H,12H2,(H,13,14)

Upstream product

• 36823-88-8 4-(trifluoromethoxy)benzoyl chloride 
• 780-31-4 methyl 4-(trifluoromethoxy)benzoate 
• 330-12-1 4-trifluoromethoxybenzoic acid 

Downstream Products

• 587-18-8 4-trifluoromethoxy-benzoic acid ethyl ester 
• 1609548-39-1 C₃₃H₃₅F₄N₅O₂S 
• 1571022-03-1 6-methyl-1-((2-(4-methylpiperazin-1-yl)pyridin-4-yl)methyl)-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)pyridin-2(1H)-one 
• 1571031-80-5 1-((2-chloropyridin-4-yl)methyl)-6-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)pyridin-2(1H)-one 
• 1571031-84-9 2-(2-((2-chloropyridin-4-yl)methoxy)-6-methylpyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazole 
• 1571031-76-9 6-methyl-3-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)pyridin-2(1H)-one 
• 1571034-75-7 C₂₆H₂₄F₃N₅O₃ 
• 1571034-81-5 5-(5-(4-(trifluoromethoxy)phenyl)-1,3,4-oxadiazol-2-yl)pyridin-2(1H)-one 
• 1571031-72-5 6-methyl-2-oxo-N'-(4-(trifluoromethoxy)benzoyl)-1,2-dihydropyridine-3-carbohydrazide 

Relevant articles and documents

Synthesis of benzoyl hydrazones having 4-hydroxy-3,5-dimethoxy phenyl ring, their biological activities, and molecular modeling studies on enzyme inhibition activities

Hydrazone compounds have high capacity in terms of antioxidant activity and enzyme inhibition activities such as anticholinesterase, tyrosinase, and urease. In this study, benzoyl hydrazones compounds (7a-7m) were synthesized starting from 3,5-dimethoxy-4

Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer's disease

Novel N-Benzylpyrrolidine hybrids were designed, synthesized, and tested against multiple in-vitro and in-vivo parameters. Among all the synthesized molecules, 8f and 12f showed extensive inhibition against beta-secretase-1 (hBACE-1), human acetylcholinesterase (hAChE) & human butyrylcholinesterase (hBuChE). These molecules are also endowed with significant AChE-peripheral anionic site (PAS) binding capability, blood-brain barrier permeability, potential disassembly of Aβ aggregates along with neuroprotection ability on SHSY-5Y cell lines. Results of the Y-Maze and Morris water maze test concluded that compounds 8f and 12f ameliorated cognitive dysfunction induced by scopolamine and Aβ. The ex-vivo activity was executed on rat's brain homogenate indicating a reduction in AChE level and oxidative stress. The pharmacokinetic investigation ascertained considerable oral absorption profile of the lead 12f. The results of the in silico docking studies and molecular dynamics simulations demonstrated stable interactions of compounds 8f and 12f with the target residues of hAChE, hBuChE and hBACE-1.

SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clinically relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clinical drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.