175277-27-7 Usage
Uses
Used in Organic Synthesis:
6-FORMYL-2-(METHYLSULFANYL)NICOTINONITRILE is used as a versatile intermediate in organic synthesis for the creation of various heterocyclic compounds. Its unique structure allows for multiple synthetic pathways, contributing to the development of new chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 6-FORMYL-2-(METHYLSULFANYL)NICOTINONITRILE is utilized as a precursor in the development of potential therapeutic agents. Its biological activity and reactivity make it a promising candidate for the treatment of various diseases, offering new avenues for drug discovery and medicinal chemistry.
Used in Medicinal Chemistry:
6-FORMYL-2-(METHYLSULFANYL)NICOTINONITRILE is employed in medicinal chemistry to explore its potential as a therapeutic agent. Its unique properties and structure provide opportunities for the design and synthesis of novel compounds with potential applications in treating a range of medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 175277-27-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,2,7 and 7 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 175277-27:
(8*1)+(7*7)+(6*5)+(5*2)+(4*7)+(3*7)+(2*2)+(1*7)=157
157 % 10 = 7
So 175277-27-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H6N2OS/c1-12-8-6(4-9)2-3-7(5-11)10-8/h2-3,5H,1H3
175277-27-7Relevant academic research and scientific papers
Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists
Asano, Masayoshi,Nakamura, Tsuyoshi,Sekiguchi, Yukiko,Mizuno, Yumiko,Yamaguchi, Takahiro,Tamaki, Kazuhiko,Shimozato, Takaichi,Doi-Komuro, Hiromi,Kagari, Takashi,Tomisato, Wataru,Inoue, Ryotaku,Yuita, Hiroshi,Oguchi-Oshima, Keiko,Kaneko, Reina,Nara, Futoshi,Kawase, Yumi,Masubuchi, Noriko,Nakayama, Shintaro,Koga, Tetsufumi,Namba, Eiko,Nasu, Hatsumi,Nishi, Takahide
scheme or table, p. 3083 - 3088 (2012/06/04)
We have previously disclosed 1,2,4-oxadiazole derivative 3 as a potent S1P3-sparing S1P1 agonist. Although compound 3 exhibits potent and manageable immunosuppressive efficacy in various in vivo models, recent studies have revealed that its 1,2,4-oxadiazole ring is subjected to enterobacterial decomposition. As provisions for unpredictable issues, a series of alternative compounds were synthesized on the basis of compound 3. Extensive SAR studies led to the finding of 1,3-thiazole 24c with the EC50 value of 3.4 nM for human S1P1, and over 5800-fold selectivity against S1P3. In rat on host versus graft reaction (HvGR), the ID50 value of 24c was determined at 0.07 mg/kg. The pharmacokinetics in rat and monkey is also reported. Compared to compound 3, 24c showed excellent stability against enterobacteria.
