175278-28-1

Basic information

• Product Name: 5-FLUORO-2-METHYLBENZAMIDE
• Synonyms: 5-FLUORO-2-METHYLBENZAMIDE;Benzamide, 5-fluoro-2-methyl- (9CI);5-Fluoro-2-methylbenzamide 97%;5-Fluoro-2-methylbenzamide97%;2-Carbamoyl-4-fluorotoluene, 5-Fluoro-o-toluamide
• CAS NO: 175278-28-1
• Molecular Formula: C8H8FNO
• Molecular Weight: 153.15
• Product Categories: AMIDE;HALIDE
• Mol File: 175278-28-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 120 °C
• Boiling Point: 214.6 °C at 760 mmHg
• Flash Point: 83.6 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 0.155mmHg at 25°C
• Refractive Index: 1.534
• PKA: 15.47±0.50(Predicted)
• CAS DataBase Reference: 5-FLUORO-2-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2-METHYLBENZAMIDE(175278-28-1)
• EPA Substance Registry System: 5-FLUORO-2-METHYLBENZAMIDE(175278-28-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 175278-28-1(Hazardous Substances Data)

Usage

General Description

5-FLUORO-2-METHYLBENZAMIDE is a chemical compound with the molecular formula C8H8FNO. It is an organic compound with a fluorine atom attached to the benzene ring and a methyl group attached to the amide functional group. 5-FLUORO-2-METHYLBENZAMIDE is commonly used in pharmaceutical research and drug development, particularly in the synthesis of potential anti-cancer and anti-inflammatory agents. It has also been investigated for its potential as an anti-bacterial and anti-fungal agent. The precise biological and pharmacological activities of 5-FLUORO-2-METHYLBENZAMIDE are still under investigation, and further research is needed to fully understand its potential applications in medicine and other fields.

InChI:InChI=1/C8H8FNO/c1-5-2-3-6(9)4-7(5)8(10)11/h2-4H,1H3,(H2,10,11)

Upstream product

• 33184-16-6 5-fluoro-2-methylbenzoic acid 
• 22062-54-0 (5-fluoro-2-methylphenyl)methanol 
• 77532-79-7 3-fluoro-6-methylbenzonitrile 
• 530-62-1 1,1'-carbonyldiimidazole 

Relevant articles and documents

A “universal” catalyst for aerobic oxidations to synthesize (hetero)aromatic aldehydes, ketones, esters, acids, nitriles, and amides

Functionalized (hetero)aromatic compounds are indispensable chemicals widely used in basic and applied sciences. Among these, especially aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides represent valuable fine and bulk chemicals, which are used in chemical, pharmaceutical, agrochemical, and material industries. For their synthesis, catalytic aerobic oxidation of alcohols constitutes a green, sustainable, and cost-effective process, which should ideally make use of active and selective 3D metals. Here, we report the preparation of graphitic layers encapsulated in Co-nanoparticles by pyrolysis of cobalt-piperazine-tartaric acid complex on carbon as a most general oxidation catalyst. This unique material allows for the synthesis of simple, functionalized, and structurally diverse (hetero)aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides from alcohols in excellent yields in the presence of air.

Nitrile Hydration Reaction Using Copper Iodide/Cesium Carbonate/DBU in Nitromethane-Water

The catalytic nitrile hydration (amide formation) in a copper iodide/cesium carbonate/1,8-diazabicyclo[5.4.0]undec-7-ene/nitromethane-water system is described. The protocol is robust and reliable; it can be applied to a broad range of substrates with high chemoselectivity.