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175278-33-8

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175278-33-8 Usage

General Description

2-(Difluoromethoxy)bromobenzene is a chemical compound that is commonly used in various scientific research and industrial practices due to its unique properties. 2-(DIFLUOROMETHOXY)BROMOBENZENE belongs to the class of organic compounds known as phenylpropanes which are aromatic compounds containing a phenylpropane moiety. Its molecular formula is C7H5BrF2O and its molecular weight is 225.014 g/mol. It features bromine bonded to a benzene ring and a differently substituted carbon, with fluorine atoms attached to the methoxy group. The presence of these halogens makes 2-(Difluoromethoxy)bromobenzene a crucial component in several chemical reactions, such as Suzuki couplings, making it a significant substance in the realm of organic synthesis. It is typically available in a liquid form and needs to be handled with care due to its reactivity.

Check Digit Verification of cas no

The CAS Registry Mumber 175278-33-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,5,2,7 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 175278-33:
(8*1)+(7*7)+(6*5)+(5*2)+(4*7)+(3*8)+(2*3)+(1*3)=158
158 % 10 = 8
So 175278-33-8 is a valid CAS Registry Number.
InChI:InChI:1S/C7H5BrF2O/c8-5-3-1-2-4-6(5)11-7(9)10/h1-4,7H

175278-33-8 Well-known Company Product Price

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  • Alfa Aesar

  • (B23174)  1-Bromo-2-(difluoromethoxy)benzene, 97+%   

  • 175278-33-8

  • 2g

  • 566.0CNY

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  • Alfa Aesar

  • (B23174)  1-Bromo-2-(difluoromethoxy)benzene, 97+%   

  • 175278-33-8

  • 10g

  • 2093.0CNY

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175278-33-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Bromo-2-(difluoromethoxy)benzene

1.2 Other means of identification

Product number -
Other names 1-bromo-2-(difluoromethoxy)benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:175278-33-8 SDS

175278-33-8Relevant articles and documents

KRAS G12D INHIBITORS

-

Paragraph 01125, (2021/03/05)

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Catalytic radical difluoromethoxylation of arenes and heteroarenes

Lee, Johnny W.,Zheng, Weijia,Morales-Rivera, Cristian A.,Liu, Peng,Ngai, Ming-Yu

, p. 3217 - 3222 (2019/03/21)

Intermolecular C-H difluoromethoxylation of (hetero)arenes remains a long-standing and unsolved problem in organic synthesis. Herein, we report the first catalytic protocol employing a redox-active difluoromethoxylating reagent 1a and photoredox catalysts for the direct C-H difluoromethoxylation of (hetero)arenes. Our approach is operationally simple, proceeds at room temperature, and uses bench-stable reagents. Its synthetic utility is highlighted by mild reaction conditions that tolerate a wide variety of functional groups and biorelevant molecules. Experimental and computational studies suggest single electron transfer (SET) from excited photoredox catalysts to 1a forming a neutral radical intermediate that liberates the OCF2H radical exclusively. Addition of this radical to (hetero)arenes gives difluoromethoxylated cyclohexadienyl radicals that are oxidized and deprotonated to afford the products of difluoromethoxylation.

2-Chloro-2,2-difluoroacetophenone: A non-ODS-based difluorocarbene precursor and its use in the difluoromethylation of phenol derivatives

Zhang, Laijun,Zheng, Ji,Hu, Jinbo

, p. 9845 - 9848 (2007/10/03)

A novel and non-ODS-based (ODS = ozone-depleting substance) preparation of 2-chloro-2,2-difluoroacetophenone (1) was achieved in high yield by using 2,2,2-trifluoroacetophenone as the starting material. Compound 1 was found to act as a good difluorocarbene reagent, which readily reacts with a variety of structurally diverse phenol derivatives 4 in the presence of potassium hydroxide or potassium carbonate to produce aryl difluoromethyl ethers 5 in good yields. This new and easy-to-handle synthetic methodology offers an environmentally friendly alternative to other Freon- or Halon-based difluoromethylating approaches.

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