175288-02-5Relevant academic research and scientific papers
A novel synthesis of isoquinolines containing an electron withdrawing substituent
Kohno, Harumichi,Yamada, Koichiro
, p. 103 - 117 (1999)
3,4-Dihydroisoquinolines (10, 13) and isoquinolines (11), having various electron withdrawing substituent were synthesized in two steps from N- benzenesulfonyl- or N, N-dimethylsulfamoyl-β-phenethylamines (2 and 5). A novel cyclization method using ethyl chloro(methylthio)acetate (1) in the presence of SnCl4 as Lewis acid, followed by acid or base treatment provides the title compounds in good yield.
Preparation of 1,7-disubstituted-1,2,3,4-Tetrahydroisoquinolines
Heer, Jag P.,Harling, John D.,Thompson, Mervyn
, p. 2555 - 2563 (2007/10/03)
A simple procedure for the preparation of 1,7-disubstituted- 1,2,3,4-tetrahydroisoquinolines from 3,4-dihydroisoquinoline (2) is presented. This strategy overcomes the limitation of cyclisation approaches which generally require electron rich ring systems
A novel cyclization of electron deficient N-benzenesulfonyl-β-phenethylamines using ethyl chloro(methylthio)acetate. Synthesis of ethyl 1,2,3,4-tetrahydroisoquinoline-1-carboxylates
Kohno, Harumichi,Sekine, Yasuo
, p. 141 - 144 (2007/10/02)
The reaction of electron deficient N-benzenesufonyl-β-phenethylamines (2) with ethyl chloro(methylthio)acetate (1) gave ethyl 2-benzenesulfonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylates (3) in high yields. We examined the effects of a substituent on t
