175291-54-0

Upstream product

• 125760-26-1 N-Fmoc serine phenacyl ester 
• 108549-21-9 benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite 
• 73724-45-5 N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine 
• 70-11-1 α-bromoacetophenone 
• 158171-13-2 benzyl 2,2,2-trichloroethyl diisopropylphosphoramidite 
• 100-51-6 benzyl alcohol 

Downstream Products

• 158171-17-6 {(S)-2-(Benzyloxy-hydroxy-phosphoryloxy)-1-[(S)-1-(di-p-tolylmethyl-carbamoyl)-ethylcarbamoyl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 158171-14-3 (S)-3-(Benzyloxy-hydroxy-phosphoryloxy)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 

Relevant academic research and scientific papers

Preparations of Nα-Fmoc-O-[(benzyloxy)hydroxyphosphinyl] β-hydroxy α-amino acid derivatives

Nα-Fmoc-O-[(benzyloxy)hydroxyphosphinyl]serine and Nα-Fmoc-O-[(benzyloxy)hydroxyphosphinyl]threonine were prepared in order to be utilized for the synthesis of phosphoserine- or phosphothreonine-containing peptides based on the Fmoc-mode pre-phosphorylation strategy. These derivatives were obtained as crystalline compounds, which are favorable for use as building blocks for an automated peptide synthesis by a solid-phase method.

An Efficient Procedure for Solid Phase Synthesis of Phosphopeptides by the Fmoc Strategy

The Fmoc-mode solid-phase method was succesfully applied to establish a practical procedure for the synthesis of phosphopeptides.Both Fmoc-phosphoserine with free phosphoric moiety and its monobenzyl phosphate derivative were examined as one of starting materials for the synthesis of peptides.The employment of the latter gave better result in respects of the yield and purity of the product than that obtained with the former.