1753-63-5

Usage

Structure

Pyridinone derivative containing a bromophenylmethyl group

Potential uses

Pharmaceutical and agrochemical industries due to its biological activity

Application

Building block in organic synthesis for the preparation of other compounds

Utilization

Research and development as a starting material for the synthesis of new molecules with potential medicinal or agricultural applications.

Upstream product

• 142-08-5 2-hydroxypyridin 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 1628-89-3 2-methoxypyridine 

Downstream Products

• 114325-76-7 9-(2-Bromo-benzyl)-9-aza-tricyclo[6.2.2.0^2,7]dodeca-2,4,6,11-tetraen-10-one 

Relevant academic research and scientific papers

Regioselective synthesis of N-alkyl pyridones

The regioselective synthesis of N-alkyl pyridones can be facilitated by alkylation of 2-methoxypyridines with activated halides. The syntheses are facile and high yielding with no traces of 2-alkoxypyridines.

Scope of Tandem Cycloaddition/Radical Cyclization Methodology

Tandem cycloaddition/radical cyclization is an effective strategy for the rapid assembly of a wide variety of ring systems.To set up the reagents for this sequence, it is necessary to include a potential radical site in one of the two cycloaddition partners, located at an appropriate distance from a new double bond that will be formed in the cycloaddition step.Examples in which the cycloaddition step is or and in which the radical cyclization creates 5-, 6-, or 7-membered rings are described.Examples of the tandem methodology carried out in a completely intramolecular mode are also described.

Tandem Cycloaddition/Radical Cyclization, a Widely Applicable Strategy for the Rapid Assembly of Polycyclic Systems

By treating a diene (or 1,3-dipole) that contains an appropriately located potential radical site successively with a dienophile (or dipolarophile) and a radical source one can construct a variety of polycyclic systems in two steps.