17533-08-3

Usage

Uses

Used in Pharmaceutical Industry:
2,4,5-Trifluoroiodobenzene is used as a starting material for the synthesis of organic compounds that have potential applications in the pharmaceutical industry. Its unique structure with fluorine and iodine atoms allows for the creation of new molecules with specific properties that can be utilized in the development of drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 2,4,5-Trifluoroiodobenzene is used as a precursor in the synthesis of compounds that can be employed in the development of pesticides, herbicides, and other agricultural chemicals. The presence of fluorine atoms in its structure can contribute to the enhancement of the biological activity and selectivity of these compounds.
Used in Scientific Research:
2,4,5-Trifluoroiodobenzene is used as a research compound in various scientific studies. Its unique properties and reactivity make it a valuable tool for exploring new chemical reactions, understanding the effects of fluorination on molecular properties, and investigating the potential applications of fluorinated compounds in different fields.

InChI:InChI=1/C6H2F3I/c7-3-1-5(9)6(10)2-4(3)8/h1-2H

Upstream product

• 367-34-0 2,4,5-trifluoroaniline 
• 367-23-7 1,2,4-trifluorobenzene 

Downstream Products

• 17533-02-7 1,2,4,7-Tetrafluor-fluoren-9-on 
• 333447-49-7 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2,4,5-trifluorobenzene 
• 333447-48-6 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2,4,5-trifluorobenzene 
• 868071-17-4 3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybutanoic acid 
• 1365321-45-4 C₁₅H₁₄F₃NO₂ 
• 1365321-49-8 C₁₆H₁₅F₃O₄S 
• 1365321-47-6 (R)-3-(2,4,5-trifluorophenyl)propane-1,2-diol 
• 1365321-55-6 (2S)-3-(2,4,5-trifluorophenyl)propane-1,2-diol 
• 1365321-51-2 (R)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanenitrile 
• 1283096-74-1 (S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanenitrile 
• 957025-32-0 (R)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid 
• 1365321-53-4 (R)-ethyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate 
• 1352613-29-6 (S)-ethyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate 
• 955403-59-5 3-(2,4,5-trifluorophenyl)propanal 

Relevant academic research and scientific papers

TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS

The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthama, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases. (I)

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.

Synthesis of 1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5- substituted-benzene thymidine mimics, some related α-anomers, and their evaluation as antiviral and anticancer agents

A group of unnatural 1-(2-deoxy-β-D-ribofuranosyl)-2.4-difluorobenzenes having a variety of C-5 substituents (H, Me, F, Cl, Br, I, CF3, CN, NO2, NH2), designed as thymidine mimics, were synthesized for evaluation as anticancer and antiviral agents. The coupling reaction of 3,5-bis-O-(p-chlorobenzoyl) 2-deoxy-α-D-ribofuranosyl chloride with an organocadmium reagent [(2,4-difluorophenyl)2Cd] afforded a mixture of the α- and β-anomeric products (α:β = 3:1 to 10:1 ratio). Treatment of the α-anomer with BF3·Et2O in nitroethane at 110-120°C for 30 min was developed as an efficient method for epimerization of the major α-anomer to the desired β-anomer. The 5-substituted (H, Me, Cl, I, NH2) β-anomers exhibited negligible cytotoxicity in a MTT assay (CC50 = 10-3-10-4 M range), relative to thymidine (CC50 = 10-3-10-5 M range), against a variety of cancer cell lines. In contrast, the 5-NO2 derivative was more cytotoxic (CC50 = 10-5-10-6 M range). A number of 5-substituted β-anomers, and some related α-anomers, that were evaluated using a wide variety of antiviral assay systems [HSV-1, HSV-2, varicella-zoster virus (VZV), vaccinia virus, vesicular stomatitis, cytomegalovirus (CMV) and human immunodeficiency (HIV-1, HIV-2) viruses], showed that this class of unnatural C-aryl nucleoside mimics are inactive antiviral agents.